PPAR Delta (Medical Guru's I Have a Question)

I heard on the radio about a year ago that there was some stuff (PPAR DELTA) that they gave lab rats that turned them into supremice.

And I’m not talking about the mice that became muscle mice… these mice became more like Lance Armstrong (I apologize for this reference for reasons you’ll read in a moment, but it was the best I could think of)

These genetically enhanced mice ended up with the following attributes…

  • more than double the cardio endurance of the “normal” lab rat in both time and distance.

  • increased lean muscle mass

  • reversed diabetes in diabetic mice

-reversed arteriosclerosis (sp?) or more commonly “heart disease” in diseased mice

-increased immune response

-gave mice the ability to eat a diet with three times the caloric intake, yet the mice only showed minimal weight gain (they retained their increased cardio fitness too)

-obese mice became “normal” sized and gained all of the above attributes.

However there was one drawback…

In mice that were geneticly designed to develop colon cancer, these mice had twice the amount of polyps and these polyps were also larger. Even though this occured these mice were no more likely or unlikely to develop full blown cancer (even though they were genetically designed to be predisposed to cancer. hence the Lance apology)

Additionally, normal healthy mice that were given PPAR delta didn’t develop cancer even though they developed the precancerous polyps.

I’ve been trying to follow the development of the study but researchers (as far as I can tell) are focusing on PPAR Beta and PPAR Gamma.

From what I understand Beta and Gama aren’t as effective. What gives?

Why the cooling on PPAR Delta research?

As you can tell, I’m not medically inclined but I think I can grasp the benefits of this stuff.

What does anyone know about PPAR Delta? Why is it on the back burner?

I’ll post medical websites that refer to PPAR Delta soon…

http://forbes.com/business/free_forbes/2004/0621/162.html