I see someone else has been watching the Monk Marathon!
Monk also talks about his childhood sometimes, and you can tell that he was quite a neurotic kid/young adult. You have to wonder how he managed to snag Trudy, who was, according to flashbacks, quite the bombshell. (Awful, going-to-hell pun intended.)
I think the idea that he’s always been this way, to a degree, enriches the possibilities for the show’s future. We’re not going to see him fully recover, but we are going to see him get better. It’ll be interesting to see what brings him peace and why, and how the people in his life act as equalizing forces in different ways. We can already see that Natalie (his current nurse) has a different effect on Monk than Sharona (his former nurse) had.
Also, I like the fact that this show, which revolves around its main character, does not require its main character to have a romantic life. Or, rather, that his (very marginal) romantic life is almost entirely centered around his dead wife.