Definitely do not mess with the Zorg flotillas that include fighters unless you have really pimped out your ride. They’re among the deadliest foes, since they can jump behind you out of your firing arc, and they sport shields, making them hard to kill.
In general, avoiding fights is a good idea until you have some upgrades in place – especially shielding and weapons. Better drives are good as well, because if you can outrun the enemy, you can control how you engage with them. It’s much like “having the weather gage” in the age of sail.
One tactic to consider is putting a good drive on a smaller ship – one of the fighter is ideal – and using that one as a decoy. Enemies target on the closest ship, and you can use that to distract them. Get a fighter out in front of your formation, then take the enemy off to the side, while your other ship(s) bear in on the side of the enemy flotilla. This keeps you outside of their weapon firing arcs and them inside yours.
One weapon to look for is the Particle Vortex Cannon. The PVC was my favorite in Strange Adventures, and it’s still the king in Weird Worlds (the Multi-Missile Launcher is nice, but I loves me some PVC). The PVC is the gun that shoots spinning disks that emit lightning bolts. You’ll see it used against you by the red Tan Ru ships (also ones to avoid, as massed PVC fire will eat through even the hardiest shieding in a trice).
And be sure to try out ramming. There are two ships you can get that are ram-capable – the Bloodfang and the Damocles. The Damocles is a special event ship, and it’s huge and slow, so not a great rammer. But the Bloodfang is great. Put a good shield on it, good drives and send it after the enemy. If you can cloak it, it’s totally awesome. Bear in mind that ramming works better against the rear or side of an enemy ship.
You can ram with other ships, but they take more damage because they’re not built for ramming, and are fairly likely to be taken out with the target, unless you have a really good shield on them (the Meson Lattice shield is good for this, as it’s the second-toughest after the Temporal Flux shield, and it regenerates, which the TF shield does not).
Heh. Can you tell I have played a lot?