I’ll write as much as I can and let others fill in all the blanks:
Lynnette Scavo is the harried mother of three wild boys and a baby girl, married to Tom. She just recently went back to work and left Tom home as a house-husband. Lynnette is quite a schemer at work and at home. She doesn't want to be too hard on her kids because her mother was hard on her and her sisters.
Bree Van de Kamp was married to Rex, who died after taking the wrong meds which were deliberately given to him by a pharmacist named George who had a psychotic attraction to Bree. Rex died thinking Bree had killed him, since they’d had many difficulties in their marriage. They had two kids, Andrew and Danielle. Andrew is an angry kid who was sent away to a camp for troubled teens. He has since come out.
Bree is a perfectionist and never wants to break down or lose control in public, although she did once.
Susan Myer is a very neurotic, needy divorced mom with one teen daughter, Julie. Susan just recently found that her biological dad is living in town. Their attempts to reconnect have not gone too well. Susan had a thing going with a plumber named Mike who was also trying to find out what had happened to a woman named Mary Alice Young; she is the narrator of the show and had killed herself in the premiere. Turns out that she and her husband Paul had taken in a baby boy named Zach whose mother tried to come back for him when he was about 4 or 5. They killed her and hid the body. For years, Zach had no idea that he was not their biological child. He had an unhealthy interest in Julie Myer for a while. Susan tricked him into leaving town to look for his dad, who had gone missing for a while. (Mike had abducted him and forced the truth about Zach from him)
Susan’s ex husband has been with her arch-nemesis Edie for a while now. Edie and susan have been at each other’s throats nearly since the show began. Susan had burned down Edie’s house accidentally. I think Susan was also responsible (?) for the death of Edie’s nosy friend Mrs. Huber.
Gabrielle and Carlos are another married couple with a lot of differences but they are still together, even though Carlos spent time in jail over some money matters. Gabrielle wants the best of everything and had been cheating on Carlos with the gardener. Yes, Carlos found that out. Gabrielle recently suffered a miscarriage after falling down the stairs when she found Caleb Applewhite in her house.
Caleb is the mentally challenged son of Betty Applewhite, a woman who just moved in earlier this season. Her other son and her had been keeping Caleb in the basement of their home because he’d had something to do with a woman’s death. We’re kinda murky on the details of this so far.
The women, with the exception of Betty, get together at Bree’s house for cards and a potluck now and then.
That’s all I can do for now. Hope it helps a bit.