At a lot of institutions, three-digit course numbers beginning with a leading zero frequently indicate “nonspecialist” or “non-major” courses, as opposed to the introductory courses in the regular program of study that constitute the “100-level” sequence.
So, for example, Physics 120, 121, 122, 123 could be the standard four-course sequence for beginning physics majors, while Physics 051 and 053 are less technical courses aimed at non-science majors interested in learning some general information about particular subjects in physics.
As suranyi notes, some highly prestigious institutions like Caltech have made kind of a point of retaining an earlier or idiosyncratic course numbering system that doesn’t follow this “100-level, 200-level, etc.” pattern, as part of their “brand”. For instance, Harvard also still uses 1- and 2-digit course numbers, while geek-happy MIT uses decimal fractions as course numbers, with the integer part being the number of the department or “course” it’s offered in. So, for example, Physics is designated “Course 8” at MIT, and the first introductory physics course is numbered 8.01.

