Žižkov and Vinohrady are nice, just want to make sure you’re aware of the distance being a factor. When I was there and went to visit my friend who lived on the other side of the river in Žižkov it was pretty much a stay all day thing, kind of what I imagine it’s like visiting Manhattan when you live in Brooklyn. I worked in the Mala Strana and lived in Řepy in Prague 6 about a 40 minute tram ride away. I’m not trying to talk you out of anything, mind you, just letting you know.
How you’re getting to and from work should be a consideration wherever you’re living. If you live near a Metro station and your job is near a Metro station on that same line, or just a short tram ride away, that’s fantastic. If you’re in a situation where don’t live near a tram or Metro and have to walk to one, then take a tram, then get off and get on a different tram, then get off and get on a Metro, then get off and get on yet another tram, then walk a half mile to work, it can be a tedious and time consuming daily ordeal even though your work and job are relatively not all that far as the crow flies.
All that said, you’re going to have the time of your life! Prague is a wonderful place to be. I envy you a little bit.