While the news isn’t reassuring, it did give me the opportunity to use that thread title
Linky
TL;DR: The Gilead medication remdesivir isn’t charting very successfully in medication trials.
While the news isn’t reassuring, it did give me the opportunity to use that thread title
Linky
TL;DR: The Gilead medication remdesivir isn’t charting very successfully in medication trials.
From what I’ve read, the study suffered low enrollment and thus was halted. Why and how one would have low enrollment in a study like this would be very interesting, but I’ve seen that happen when some numbnuts includes inclusion/exclusion criteria that make no sense, or an inappropriate test (I worked on a cardiac product once where our Chief Medical Officer wrote the protocol to require a slew of “can’t hurt” tests, which irritated the subjects and caused a number to withdraw consent)
But there are other studies ongoing with this drug, some of which are still claiming success. So there’s hope.
And it’s a good reinforcement of why numerous trials of sufficient size are so important, and why the “OMG A CURE!” headlines are so irresponsible.
It just takes time to get to the answer. Deal with it.*
*Not directed at the OP
From what I read earlier, some of the early trials appeared quite promising, so it’s too soon to reach conclusions one way or the other. Last I saw many of the proposed remdesivir trials were still in the “recruiting” stage.
I don’t know. The drug has proven useful with rats and monkeys, it was identified as the most promising candidate for being a treatment by computer modeling, and it seemed to have good results in the recent New England Journal study.
In terms of that last, there was no control group but they did specifically follow each patient for 28 days to keep track of their status and they all performed much better than publicly available numbers of the usual progression of the disease would predict. There is a quasi-control group for the case.
This report seems like a strange outlier compared to everything else (though, “everything else” is a bunch of unreliable things) and it comes from a country known for falsifying data, and who we are engaged in a war with.
It might be a genuine and honest look at the results. Humans aren’t rats nor monkeys. But, I think I’d prefer to stick to results on the drug from Western countries, for the moment. Only if those seem to be in a similar range does it feel like we should include the Chinese data.
Where can I then find ease for my sin sick soul?
I always obtain great relief by carving deities from downed wood or other compacted organic matter. (Dried bear poop? Maybe.) I offer them sacrifices and pray for benefices. If they don’t deliver, into the fire pit with-em! My soul is much eased. Hashish helps too.
Very simple: this was a Chinese study and China has Covid-19 under control with very few new cases. There are several other studies in progress in Europe and the U.S…
Nevermore
Now they have room on their schedule to investigate anal UV lights and injectable Lysol.