Sherlock Holmes and Sherlock Holmes. Throw House in there too.
How about Kramer and Jim Ignatowski…I’m not sure if it would be resolved or if it were, whether either would know it.
Jean Luc Picard and Professor X
The Nash Rambler from the song “Beep Beep” and you got it, the Road Runner in the Road Runner cartoons…“Beep Beep,” “Beep Beep.”
“Beep Beep.”
“Beep Beep?”
“Beep Beep!”
“BEEP BEEP!”
“BEEP BEEP!”
I think you can see where this is going.
LJ Gibbs and Harry Callahan. I would expect it to be very quiet with lots of squinting.
Goren from L&O:CI and Hannibal Lector.
Frank Costanza and Arthur Spooner.
That was a very good episode of Blunt talk.
DS9:
Dr. Bashir and Garak
Quark and Odo
Rocky vs. Rambo. Or Pennywise (the clown from IT) vs. Frank-N-Furter from Rocky Horror.
Jessica Tate from Soap and Endora from Bewitched.
Jim Ignatowski and Leo from That 70s Show.
Or Leo and Archie Bunker.
House and Sheldon Cooper.
Really? Tell me more.
Frank Pembleton from Homicide and Red from The Blacklist. They’re both so erudite and eloquent, with (different) strong internal moral codes that fuel them, and they know just how and when to shift between charm and force.
Hell, throw in Sheldon Cooper. I’m one of those people who want to watch the world burn.
And Spencer Reid.
ETA: And let’s put Leslie Winkle in there. I miss her and Sheldon’s debates.
Xena TWP and TOS Kirk
Moderated by Ellen the Generous.
… I’ll leave the auto correct as is… 
.
Cousin Furio and Tuco.
or
Tony Soprano and Al Swearengen.
Al Bundy and Jay Pritchett.
Ed O’Neil is essentially playing the same character in Modern Family: older guy, hot young wife, big house, only this time he’s happy and loves his wife. I never bought it when people came over to the Bundy’s and complained about what a terrible life they had. They lived in Chicago in a 2 story house on one income. For that money, the Bundy’s had a spectacular house