Do you mean uncomfortable as in awkward or painful?
I just got done being sick for a month (bacterial infection) after moving to Sacramento. As if the huge lymph glands, fever, and dizziness weren’t enough I developed reactions to both medications I took. The first one decided to bust out right before I finished the last pill. Bactrim made me break out in a bright red rash covering my entire body and I was lucky to get a few hours of sleep while I was so damned itchy. After hopping me up on Benedryl the doctors gave me Amoxicillin. Nothing could be as bad as itching all over your skin, right? Wrong. Try vaginal irritation (understatement of the year) for 5 days straight. NOTHING helped. Everything but yogurt made it worse. I was lucky to get over an hour of sleep each night. I felt like a zombie. After the third night I kind of got used to the lack of sleep, but it was still the worst month I’ve ever had.