Henry Winkler could be David Schwimmer’s father. If you squint.
I was once convinced by someone that this was in fact the case, while drunk.
I’ve always insisted that Jerry Doyle and Bruce Willis are the same person. They even talk alike.
Mary Louise Parker and Elizabeth Perkins. They even play on the same show, Weeds.
Does anyone know if they play sisters?
Jack Nicholson and Bruce Willis could be father and son. Since they both grew up in New Jersey with unknown parentage, I often wonder if there is a genetic connection (Nicholson was born to a 15 year old, unknown father; Willis was adopted).
I would have said Robert Sean Leonard and Sean William Scott are family.
I thought Ray Liotta and Johnny Depp made a believeable father/son in Blow…
Tom Hanks and Juliette Lewis.
They were in a television show (for about 10 minutes) as father and son once.
Noooooooooooooooooooooooooooo!
OK, you probably don’t recognize them by name, but you might know them by character.
Ryan Reynolds (who played Berg on “Two Guys and a Girl”) could easily be the older brother of Shawn Ashmore, who plays Bobby Drake/Iceman in the X-Men movies.
Sam Waterston http://imdb.com/gallery/granitz/2412/SamWaterst_Cohen_2272467_400.jpg?path=pgallery&path_key=Waterston,%20Sam&seq=23
and Ed Norton
http://imdb.com/gallery/granitz/1894/EdwardNort_Pimen_837765_400.jpg?path=pgallery&path_key=Norton,%20Edward%20(I)&seq=6
Could play father & son.
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Uhhh…why not? I swear, it’s freaky. They could be siblings.
[QUOTE=Queen Tonya Skeet Ulrich is a poor but acceptable Johnny Depp
[/QUOTE]
I must have watched “As Good as it Gets” five times before I learned that it wasn’t my beloved Johnny. I always wondered why he had an uncredited cameo. I only found out through a thread similar to this one, and lemme tell ya I felt like the ultimate :wally
What popped into my head when I saw this thread was the quick shot of a lady last night at the Golden Globes that was either Kirstie Alley or Fergie
Okay, it makes more sense that it was Kirstie, but she was looking awfully Fergoid.
That was the same cry of despair Luke Skywalker gave in the Cloud City. The awful realization of a truth too horrible to be incorrect.
That was the same cry Abdul Alhazered gave at the end of his wanderings in the desert when he sat down to write Al Azif.
Perhaps instead of wookin’ pa nub I should start wookin’ pa coding.
Owen Wilson and Luke Wilson could be brothers. 
Tony Hale and either John Turturro or Adam Sandler.
Will Arnett and Michael Keaton.
Chris Elliot and Daniel Stern.
Laura Dern and Helen Hunt.
Ah…I thought it sounded familiar. 
We could start a parallel thread: “I can’t believe they’re related.” Like Randy & Dennis Quaid, or Beau & Jeff Bridges. Owen & Luke Wilson seem headed that way.
Don’t forget Jeff Kober.
Natalie Portman and Keira Knightley could be sisters.
Sarah Jessica Parker and Roger Daltry.