Barf. Come on, didn’t you just flash on an image of someone doubled up over a toilet?
The word “set” apparently has the record for the most different meanings.
I hate to break it to you, WILLASS, but floccinacinihilipilification does not mean, and indeed cannot mean that. So far as I know, every word in English that ends in -ation is from Latin, denoting the act of some verb. Floccinaucinihilipilification means the act of…(going to get the OED)…hmm, it’s not in there. The OED has every word in the English language, so if something’s not in there, it isn’t a word; however, my copy is from 1973, so…
I nominate mellifluous, which means smooth and sweet, usually in application to a voice.
A fourth vote for “defenestration,” especially as used by Bill Watterson:
The monster, in its consternation,
Demonstrates defenestration,
And runs and runs and runs away.
Good poetry gives me goosebumps.
Just done some googling…
Sorry, dwalin, looks like willass was right!!!
Anyway, I have to agree with “defenestrate”, I was told that by my German teacher when I was a wee lad, he also thought it was the best world ever 
Freedom
I’ve always like the word “word”, because I wonder what they called them before that word came along.
Oh, and I believe “turn” could give “set” a run for its money. What is your source, Fuji Kitakyusho?
Yiddish words seem (to me) to impart their meaning in the pronunciation: Mench. Behave like a mench. Don’t be a :wally
Cromulent!
It’s definitely my favorite word.
Mordant
Mordants make the world colourful (they make dyes stick to cloth)
but the word sounds like the name of an alchemists pet crow.