Beantown is the one everyone’s heard of for Boston but I see it more often referred to by local media as the Hub. Wikipedia has a bunch of other nicknames but I don’t ever see anyone actually using them.
The North Shore, home of such John Hughes movies as Pretty in Pink, Ferris Bueller’s Day Off, etc.
(his son has a music studio next door to my house)
Anchorage, AK was often called ‘Anchortown’.
The Metroplex, or DFW
The Coulee Region, the La Crosse WI area of the Driftless Zone.
My friends in Ft. Collins call it “Fort Fun.”
My part of CT is called “The Quiet Corner.”
I prefer “The Naked Pueblo,” as used by one of our classic rock stations, KLPX - 96.1.
Montgomery, AL-
Monkeytown and/or The Gump
Monkeytown is an old CB name for the place; Gump became more popular after Forrest, of course.
I’m not allowed into the Shire, as I refuse to wear the flag as a cape and lack the requisite Southern Cross tattoo. 
As you might guess, I live in the Inner West, and I am in Innerwestie. (Newtown, as it happens.)
ETA a smilie, cause it looked harsh without one.
Tel-Aviv, particularly my part of Tel-Aviv - basically anywhere within an easy Segway ride of Cafe Tamar on Sheinkin St. - is often referred to as “the Bubble”, because of the way we supposedly shut ourself off from the problems of the rest of the country. It’s bullshit, of course (we used to get as many suicide bombings as anywhere), but the stigma remains.
What’s a CB name?
The North County, not very exciting really. Although the region is known as Fingal too but that’s not really a nickname.
Havre is part of the Hi-Line, but not all of it. (In my experience, the term’s most commonly used to refer to all of Montana along the portion of Highway 2 that’s east of the Rockies.) I suppose part of rural Montana is that our ‘regions’ extend hundreds of miles.
Missoula is usually called Zoo Town.
I grew up in a lovely (sarcasm) section of Dallas officially know as Pleasant Grove. It was anything but. Locally know as ‘The Grove’, it was home to all manner of white trash. Denizens were known as Grove Rats and home of the Oak Hill Gang. The badasses from Oak Cliff wouldn’t even hang there.
Oh, also the home of “The Trap” bar. If you really wanted an ass whipping, that was the place to be.
Rochester, NY used to be nicknamed the Flour City because there were a lot of flour mills along the Genesee River. Later on the mills closed and some people were confused when they heard the name (and admittedly there were now several big garden seed companies in the city). So the nickname was changed to the Flower City.
Nowadays the seed businesses are also gone. But somehow later industries never got their due so Rochester didn’t go on to become the Mustard City, the Film City, the Contact Lens City, or the Photocopier City.
Trucker lingo, usually spoken when talking on Citizens’ Band radio, or CB.
That’s OK, a lot of the people in the Shire shouldn’t be allowed out, either. Not that leaving would occur to them.
The Burgh. The “H” is of great importance. Also the Steel City which is a misnomer nowadays, as the steeliest thing is the HQ of the Steelworkers’ Union. There are two mills still working in the area, but none are actually in the city itself.
(Pittsburgh, PA)
There was an episode of Cold Case Files that took place here in Phoenix, the Valley of the Sun. The idiotic announcer kept saying over and over “The Sun Valley”. :smack:
I can tell you, NO ONE confuses those two, and it was obvious that the writers, producers, and announcer were completely clueless. 
Well, I laughed anyway.