What topic is your favorite Great Debate?

If you had the power to host a Great Debate in which all the greatest minds of the SDMB and beyond were drawn together and have a really in depth and meaningful give and take… What topic would you like explored?

Yes, I know many people have hard and fast positions, but let’s pretend it was going to be a discussion watched and read by millions of interested people. In other words, let’s pretend that it is well worth every person’s time to respond to the same objections, even though they have done it many times before.

If you could pick what topic would be debated in just such a condition, what would it be? and Why.