I’m probably going to repeat a little of what other people have, but I’ve done lots of drugs, and during my college years tried anything I could get my hands on at least once:
Pot - One of the few drugs I really enjoyed. Depending on the type of weed you get your high can range from sleepy/lethargic to semi-energetic. I ALWAYS get the munchies.
Coke - One of my least favorite. For me, the experience was far too tense and energetic. I’m not by nature a tense person, so I didn’t like feeling stressed out when I was supposed to be having a good time.
Acid - Did a lot of this in college, and enjoyed it as long as I had some weed to come down with. This of your mind and body in an overdrive of hallucination and thinking. Only ever had one “bad” trip, and that was when a friend who didn’t know I was tripping told me about another friend who had committed suicide. I spent much of the night trying to maintain my sanity, and it wasn’t easy. Basically lucked out and had some friends that kept talking me down when I’d get out of control.
Ecstasy - Another favorite. The best way I could describe it is that everything you see, do, and touch is just about the coolest thing you’ve ever seen, done, or touched. Sex is overrated on X, at least it was for me.
Speed (Meth) - Kind of like a nightmare coke binge that just won’t stop. I only tried this once, and disliked it immensely.
Mescaline - Only tried this one once too, and think I got a bad batch. Basically didn’t do much for me.
Heroin - Never injected, just smoked it with weed. Generally made the highs higher and more lethargic.
Opium - Very similar to pot, but the laid back lethargic feeling is more powerful and lasts longer.
Shrooms - Did a bunch of these, usually by making tea. Very low key hallucinatations, very laid back. The comment by NurseCarme was very appropriate.
Have done a number of painkillers and sedatives, but you probably know those effects yourself.
And, oh yeah, drugs are bad, M’kay?