Who is the smarter, stronger, or more clever character?

Exactly.

I think a more even match for Darrin is Wilber Post. (Adman vs architect.)

(Speaking of admen, Don Draper would definitely, definitely kick Darrin’s ass.)

Agnes Kravitz versus Dr. Bellows in a suspicious-of-all-this-weirdness competition
: Bellows wins - he’s doing his actual job, monitoring the psychological health and stability of an astronaut, not spying on a neighbor. Also Bellows never breaks the law as I recall, while some of Agnes’ actions probably cross the line into peeping-Tammy territory.

I feel like Chuck Noland would be able to absolutely kick Gilligan’s ass, since Gilligan doesn’t seem to have an ounce of violence or strategy in him. Gilligan would likely be drawn to Wilson, and in a streak of paranoia, Chuck would scheme to push Gilligan off a cliff, or drown him in the ocean. Gilligan is a good source of protein too and Chuck could probably use a good bucket hat.

I’m absolutely sure My Mother the Car had way more horsepower than Mr. Ed.

OTOH, Endora would blast Jeannie 2,000 years straight back to Persia and turn her in to a permanent bit of air pollution.

I would bet on Wilber or Don Draper in a fight over Darrin.

I mentioned that earlier, I’m glad we’re on the same page.

Bob Hartley checks into Dick Loudon’t Vermont Inn. Who gets exasperated first?

Dick Loudon, he isn’t a professional. Hartley can put up with a fair amount, even from friends. But let’s be serious, they’re really the same character, aren’t they? This is not Oscar Madison vs Quincy. This is more like Lucy vs Lucy vs. Lucy vs. Lucy.

Could Dr. Zachary Smith (Lost in Space) stand a chance against the Emergency Medical Hologram (Voyager)? Perhaps in deviousness, but not much else.

“What is the nature of your medical emergency?”

“Ohhhh, the PAIN!”

Especially if you throw in Mr.Carlin and Larry, Daryl, and his other brother Daryl.

Urkel would beat Skippy as long as he has access to his technology, but even Stephan couldn’t beat Rose.

Fred Flintstone vs Hank Hill, dunno, but Peggy would whomp Wilma.

And then there is Newhart’s least remembered character, Bob from Bob. As a cartoonist, he would need to fight Henry Rush from Too Close for Comfort (with or without the Cosmic Cow puppet).

Fred was strong. Think about the foot powered rolling car. He did great at college football when well past college age already. I don’t see Hank having a chance.

Fred is a man of parts - he’s an excellent race-car driver as well

Captain Picard will patiently and quite persuasively explain why he has the superior moral position.

Captain Reynolds will grudgingly acknowledge his correctness, but give him the slip anyway.

Picard will become increasingly annoyed when this happens once per season during sweeps week.

Columbo knows that a perfect murder isn’t possible, so I don’t think he’d try.

Just the quantum level of crying would collapse the universe into a singularity.