Probably more but not necessarily ‘way more’. The car was said to be a 1928 Stanhope Touring car but was actually custom made from a Ford Model T and parts from other cars. A reference I recall from the show indicated it had a 2 stroke motor and a top speed of 25MPH. Mr. Ed could probably run faster than that carrying a lightweight jockey but perhaps quite limited while carrying someone as heavy as Wilbur. He might have been competitive pulling a cart though. Whatever the rated HP of the car engine Mr. Ed might have been able to deliver more pulling capacity than the car could at the wheels with it’s transmission, and certainly the horse would be much more maneuverable. Depending on circumstances, in a race of a fight Mr. Ed stands a decent chance of coming out ahead.
I think Detective Robert Goren of Law & Order: Criminal Intent would figure out Adrian Monk’s (of Monk) triggers and be able to exploit them to get Monk to crack.
Also just about any Star Trek captain would curb stomp Zapp Branigan in any sort of confrontation.
Marvin would be too depressed to put up any kind of fight against Data.
John Steed and any of his partners would easily outsmart and outfight Napoleon Solo and Ilya Kuryakin. Hell, Steed and any of his female partners would probably beat 60’s
Batman, Batgirl AND Robin.
A number of people with less on the ball than Steed and Etc have done that; 60’s Batman and Robin and Batgirl get captured, yessirree, they’ve sure been thwarted.
And then…
Gandalf vs Obi Wan. Gandalf wins handily, being an immortal being.
Though would Obi Wan have just taken Frodo, and the ring to mount doom by eagle ?
But Obi-Wan, you said you’d help me destroy Sauron.
Dark Lord Obi-Wan: That was true, in a manner of speaking
I disagree. Yeah, he’s caught guys who’ve overlooked an item at the scene of the crime, such that it was a fair-play mystery for the audience at home and he merely noted stuff the killer missed — but, time and again, he’s come up against case after case where he genuinely doesn’t find a tiny detail that’ll keep the killer from getting away with it. At which point Columbo shrugs and plants some false evidence to elicit a confession, or otherwise talks at the suspect until they blurt out something only the killer would know.
Which means he knows, first-hand, that it’s entirely possible to leave no slam-dunk clues for even a Columbo-type to find — at which point you can get away with it if you just shut the hell up and let your lawyer do the talking.
Battle of the corrupt cops: I think Michael Ehrmantraut (from Breaking Bad and Better Call Saul) would outsmart Vic Mackey (from The Shield)
Hm. That makes me think of Hannibal Lector as Monk’s therapist.
It’s been ages since I’ve seen the episode; I can’t remember if it was college or high school he was being sent back to, but I do distinctly recall those student players looked like not-yet-fully-grown high school students rather than college-age full-grown men. Fred just mowed them down with his superior bulk.
I just checked, it was High School. Your memory was better than mine.
Possibly not a fair comparison but George Smilie would wipe the floor with James Bond (metaphorically that is, if it came to a fight James Bond would literally wipe the floor with Smilie). But Smilie has the actual skills required in spying which rarely involve seducing beautiful women, fighting henchmen, or escaping evil villain’s layers 
Fred Sanford vs Oscar Madison in the Battle of the Grumpy Old Men. I’m going with Fred.
No chance against Dr. House (who is a thinly veiled modern Sherlock Holmes anyway) and a good box of Vicodin™.
Speaking of Sherlock Holmes, he would definitely find out what Arsène Lupin (or Fantômas, his more murderous successor) did and how, but he would not catch him/them.
And Flying Fox of the Yard would not stand a chance against even the dumbest baddie from Starsky and Hutch.
My Mother the Car would flatten My Favorite Martian like intergalactic roadkill.
I suspect the Munsters would be mincemeat in any encounter with the Addamses, Fred’s goofy good nature would be no match for Gomez’s rapier wit. Or rapier.
And while we’re blacking and whiting, I’m trying to get through the Many Loves of Dobie Gillis for reasons that I myself do not understand. I think he and Maynard would be pretty much out of their league if the Patty and Cathy Lane from the Patty Duke Show came to town.
Mr. Terrific and Captain Nice may square up against each other, but it wouldn’t come to blows—they’re too polite and timid.
Gidget could probably take Patty Duke. She seems scrappy.
The twins would ally with Zelda, and together they’d take down Thalia, clearing the field for Zelda to marry Dobie. Cathy and Patty would turn Chatsworth and Maynard into good prospects for themselves (Patty/Maynard and Cathy Chatsworth obviously). Maynard becomes a successful Beat poet, never realizing that it’s work (WORK?!?)