Indeed, the oldest recorded joke (from Sumeria about 4000 years ago) translates as something like, “Since the dawn of time, it has never happened: a young wife sits in her husband’s lap without farting.” Ha! It’s funny because it’s true.
I think they did, early on Penny asked him about it and he said the pills didn’t work.
in these comedies they only need to make a linkage of cause and effect, it doesn’t have to be strong or happen in real time.