Typically, with those fonts CDs, you can reduce the number by ~100 or more if you look through them and pick out the typefaces whose designs are extremely similar. You don’t have to look at every font. The ones that say ‘Normal’ or ‘Regular’ are enough basis for comparison. In the 1,000+ font CDs I have, I’ve been able to discard several dozen fonts by doing this.
Mac users can go another step by condensing the fonts into a smaller number of suitcases. The CD literally has 1,000 fonts fonts, but they kind of cheat-- they give you as many as five or six variations of the same basic typeface. To use font names most of us recognize, there’ll be Times, Times Italic, Times Condensed, Times Expanded, Times Bold, Times Expanded Bold, and so on. There can’t be more than 125 separate families in those CDs, but counting each variation bumps the number up past 1,000.
To clear the clutter, you can move the name-suffixed fonts out of their respective suitcases and put them into one single family-named suitcase. Instead of having eight separate font suitcases with one font file in each of them, you’ll have a single suitcase with eight font files in it.
This ability comes in handy, as the Mac OS (pre OS X, at least) can only recognize the first 128 font files in its Fonts folder. If you don’t consolidate them, it may mean that seven of your fonts will be ignored by the system software, which may be either annoying or downright problematic.
This method doesn’t allow you to save on the RAM those fonts would take when you launch your word processing or graphics program, of course; the font files have been resorted, not deleted or condensed. If the RAM’s important to you, you can delete (or store elsewhere) the the bold and italics version of the fonts, as most programs will allow you to make those modifications your text.