So I know alphafold is reasonably good at determining the tertiary structure based on the primary amino acid sequence. I don’t know if they can do quaternary structure or not.
But there are 20-22 naturally occurring amino acids that build proteins. There are virtually infinite synthetic amino acids that could be designed though. Does anyone know if synthetic amino acids in proteins is a feasible medical technology in the coming decades? has there been research on it to date?
These wouldn’t be totally synthetic proteins (at least not at first), but maybe if you replace one of the amino acids in a 70 amino acid chain with a totally synthetic amino acid it would give the protein different effects or a different half life.
of course I’m assuming you’d need quantum computers will millions of qubits to actually test this kind of thing.