Actors who've played characters who'd never get along with one another

Adam Sandler’s character from Spanglish would probably have hated every other Adam Sandler character

Mike Brady and his adulterous slaveowning Virginia adulterer from ROOTS would probably both have raised eyebrows at his preoperative transsexual character from Medical Center.

Thirty-five years after racking up an Oscar nomination for playing Milo Tindle in SLEUTH, Michael Caine played – Andrew Wyke, in SLEUTH. So we already know they’ll get along at first, and that they’ll eventually come to blows…

Similarly, Richard Hatch in Battlestar Galactica and Battlestar Galactica. Tom Zarek and Apollo don’t end up exactly on the best of terms.

And Leela was Peg Bundy? I never would have guessed.

I’m guessing that Al Freeman Jr.'s Malcolm X (from Roots: The Next Generations) and his Elijah Muhammad (from Spike Lee’s Malcolm X) may have started off friendly but would have had a falling out eventually.

Police Commissioner Tony Scali would have IA on Detective Vic Mackey’s ass so quick his head would spin.

This may be true but Vic Mackey wins this fight and sleeps with Scali’s wife while he’s at it. He also manages to get a bunch of guns and gangsters off the streets at the same time. Mackey always wins.

Heck, one Terminator wants to kill Sarah Connor, one (well, two, but the third movie was kinda dumb) wants to protect John Connor… hilarity and carnage ensues.

I don’t think JR Ewing and Tony Nelson would have had much in common.

I don’t know about that. Aren’t orcs basically mutated elves? He might not be too keen on Sauron, but I don’t think he’d take kindly to the Armies of the West, either.

Isn’t it the nature of the ring that, the more powerful the individual, the stronger the pull of the ring? And any iteration of Magneto you care to name, he’s always a very “ends justify the means” kind of guy - precisely the sort of thinking that the ring most appeals to. Even if he didn’t need it to clean up Middle Earth, he’s still going to want to get home, and take care of the mutants on Earth - and think how powerful the One Ring would be if it operated under Marvel Universe physics! It’d make a cosmic cube look like an iPod.

Two by Daniel Day Lewis: Bill the Butcher (Gangs of New York) and Cecil Vyse (A Room with a View). Not sure how they’d come into conflict, but I have a pretty clear idea who’d win…

'Twas just a wisecrack anyway, both in the OP and the post you quoted.

Detective Mills would have no patience at all with Jeffrey Goines.

I’m not sure how William “Old Shoe” Schumann would have gotten along with Larry Flynt.

How about an all-Wesley-Snipes version? Passenger 57 gets sent in to wreck Nino Brown’s operations in New Jack City, Blade drops Simon Phoenix faster than the Demolition Man can, Willie Mays Hayes doesn’t know what to make of Noxeema Jackson of WONG FOO fame…

Similarly, I don’t see neither Lord Edmund Blackadder, Mr. Blackadder, nor Capt. Blackadder getting on with Mr. Bean

The mention of the name Jeffrey reminded me…

Thy’lek Shran and the Question may have some grudging respect for each other, but neither would like Brunt, and none of them would likely be able to tolerate Herbert West, or Wayoun - though the two of them may get along well enough - and Ratchet would think the lot of them were a pain in his capacitors. The Scarecrow clearly wouldn’t get along with Question. I think he would likely get along swimmingly with Wayoun - ‘Do you think that fear gas of yours could be adapted to Klingon and Cardassian brain chemistry?’ ‘We’ll see, won’t we?’ - maybe even West, but the others would annoy him, and vice versa.

(OK, only 4 separate universes covered within that list, but 2 different time periods within the Trek verse.)

On the topic of Trek/DCAU crossovers…

The Voyager’s Doctor would likely annoy Amazo, as a pretentious little putz, though the annoyance probably wouldn’t go the other way - the Doctor would likely admire Amazo.

Hmm…More DCAU guys…

The Kurgan and Lex Luthor would loathe each other, because of their shared megalomania, and general disrespect for everyone who isn’t them. Neither of them would much like Eugene Krabs, who would probably suck up to Luthor until he realized he wasn’t going to get something out of it, and then rant against him.

Speaking of Lex Luthor, I doubt that Smallville Lex would get along any better with the DCAU Flash than the DCAU version.

Needless to say, the Joker and Luke Skywalker? Not going to get along.

I think Michael Corleone would find Tony Montana to be an arrogant, psychopathic cokehead (he wouldn’t be wrong).

Jack Nicholson as Wilbur Force vs. Col Nathan Jessep. Wilbur is ‘into’ pain and would egg on the Colonel.

John Travolta as Tony Manero vs. Vincent Vega. Two street showoffs would clash badly.

Yesterday I watched an episode of The West Wing where Jed Bartlett mentioned winning the “Badlands” a couple of times - an obvious shout out. Kit’d bring out some cigarette-in-a-Church wrath in the fictional POTUS, I reckon.

Verne Shillinger from OZ would kick the crap out of Dr. Emil Skoda from L&O, while J. Jonah Jameson would sit there and laugh about it. (J.K. Simmons)

Captain Krug would kick the shit out of Doc Emmet Brown, just for being human.