How about the continuing adventures of the Federation Time Patrol? Based a century or more farther in the future then we have gone before, the Patrol tries to preserve the timeline they’re pretty sure is the real, right, correct timeline (or is it?).
Also, I liked the bit in DS9 where we learn that Bashir’s parents had him illegally enhanced, and he’s had to hide this all his life, for fear of being kicked out of Star Fleet, having his medical licence revoked, etc. Suddenly, we learned that there was a hated, stigmtized minority group among the Earth-humans of the Federation. People who have to live in fear that their lives will be ruined if their secret is exposed.
I think in DS9 it may have been stated that Bashir was highly unusual in that he had not gone insane. In my series, yes, some enhanced people go nuts (so enhanced people have to worry if they’re sane or not), but there’s a lot more sane ones then the Earth govt officials think. They just stay closeted, as Bashir did. Some of them use their powers for good, while trying not to give themselves away. Some just look out for number one; try to achive riches and power without giving themselves away. The use-our-powers-for-good types try to find others of their kind, for company, and to work together. Hard to do, though, as everyone’s passing as normal.
The other species, Federation and otherwise, are mystified; don’t understand why the enhanced are oppressed. I think it’s supposed to be a legacy of the terrible trama of the Eugenics Wars; fear that the enhanced will try to take over. If that wasn’t established in DS9, I’ll establish it in my series.
Oh, and in any Trek series I create, there will be gay men, lesbians, and bi people around, who will be accepted as being just as normal as straight people. Same-sex marriage will be legal, accepted, taken for granted. And people who feel that they were really meant to be the other sex will be able to switch genders easily, and be fully functional as the other gender. This will be seen as a normal, routine thing that some people choose to do. Change your mind? No problem! Switching back is also easy. I think I’ll have a colony world where the in thing to do is spend some time as the other sex, just for the experience, to broaden one’s horizens.