I don’t have a dog in this fight one way or the other I’m just curious. Your body in my understanding produces new neurotransmitters at fairly regular intervals, and taking SSRI’s and other reputake inhibitors prevents reabsorption but the body responds by producing less serotonin as your body adapts to the drug. So in the long term treatment of depression are SSRI’s and drugs that function in a similar manner essentially worthless, do they even have a place in treatment of long term depression.
Here is an article on the topic:
This article is about SSRI’s I haven’t really read enough about other types of antidepressants to wager a guess about their long term efficacy, I would think the brain would always have some clever trick to bring it’s levels of various neurotransmitters to the level it likes, in spite of alternative mechanisms of action.