Can a person on wellbutrin get high on cocaine

[Wesley_Clark]

If wellbutrin is a dopamine reuptake inhibitor if a person is taking that for antidepressant reasons then takes cocaine will they still get the cocaine high due to cocaine displacing wellbutrin or will wellbutrin prevent the cocaine from working?

[deevee]

Man Wesley I’d like to see your notebook after you’ve collated all the info you’ve been collecting lately. :eek:

[Shagnasty]

This questions was answered here at Google Answers. The summary is that no one really understands it very well. That is typical with anything to do with neurotransmitter function. Those news shorts and magazine articles make it seem like we know all about neurotransmitters and that is far from the truth.

Here is a clip that I thought was relevant:

Bupropion and cocaine are both dopamine REUPTAKE inhibitors. This is
quite different than a dopamine inhibitor.

A reuptake inhibitor will prevent synaptic dopamine from being
endocytosed and removed from the synaptic cleft, the final result
being an increase in the concentration and action of dopamine between
neurons. A traditional “inhibitor” would generally either compete for
the dopamine receptor without activating it, actually deactivate the
receptor, or in some other way reduce the action of dopamine (not
something generally desirable).

[xash]

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-xash
General Questions Moderator