I don’t love Lucy.
Heroes. I tried to give it the benefit of a doubt and made it through the last episode of the first season thinking “Jesus, I just spent 22 hours watching the first 22 episodes and I could honestly give a fuck as to how this all turns out.” I did not return for the second season.
Friends. A more uninteresting group of people cannot be found.
Me too, but trying telling that to some people. You’d probably get a warmer reaction from fans of the show if you confessed to eating babies.
The Office - either version
Lost
and 95% of all other sitcoms since the early 90s too.
I tend to have kind of lowbrow tastes 
so I’m partial to sitcoms, and I actually enjoy most of the comedies that have been mentioned here. It doesn’t have to be great to make me laugh. But Two and a Half Men just plain doesn’t make me laugh.
Also, I have trouble staying awake through a whole episode of any iteration of the Law & Order franchise.
Agreed on Seinfeld. Never did find it funny, and the characters were just plain unlikeable in any and all ways.
The Office and Extras - I just can’t stand that sort of painful embarrassment humour.
Heroes. Like ZipperJJ I gave it a try and watched the first 10 or so episodes. I was completely uninterested in any of the characters, and really couldn’t give a crap about who’s on whose side. I ended up fast forwarding to when the cool stuff happened, meaning the last 3 episodes took me about half an hour.
I never saw the appeal of Buffy the Vampire Slayer.
House and CSI. Lab rats don’t carry guns and arrest and interrogate suspects.
There seems to be a large anti-Seinfeld contingent on these boards, as this and many other threads have shown. Is this an SDMB-only characteristic? Otherwise, how to explain the huge popularity of it among the general population?
(Maybe people either hate it or love it, and there are just a lot in the “love it” category, making it popular, and also a lot in the “hate it” category making them vocal in threads like these)
On House, the doctors go into patients’ homes and look for clues. I always thought that was ridiculous.
Me, either. I’ve tried watching some episodes on hulu, but I don’t get what everyone else seems to see in it. Maybe it’s generational.
Any show that features the fat slob with a hot wife.
Pretty much everything about CSI is - well, dumb, for lack of a better word. Imagine a real-life lab where people cut up long-dead bodies without protective gear on, or where long, lustrous, flowing, curly/luxuriant/shiny and uncovered hair is allowed to be, you know, long, lustrous, flowing and curly/luxuriant/shiny and uncovered whilst the head sporting it is attached to a person gathering evidence at a crime scene . . .
Mind you, I do allow myself to fantasize that David Caruso will be actually vaporized in the actual real world and that his end will be worked into the show in some way. Is that too much to hope for?
Baby eaters!
For me, it’s not that I hate Seinfeld, it’s that the show is overrated. No matter what, it is still just a sit-com: it even has a wacky neighbor which we have seen in sit-coms since the dawn of TV (and probably before that on the radio).
Current:
My Name is Earl
Family Guy
2-1/2 Men
Past:
Friends
I don’t hate any of them, I just never laugh.
Another thread in Cafe Society reminded me of another show that I dislike: MASH.
I thought the original run with Henry, Trapper John and Frank was great but after they left it quickly became a sanctimonious mess and went on and on.
Friends. It’s okay, but I just don’t understand the devotion some people had/have to it.
Will and Grace. I tried watching it once, but I couldn’t stand that annoying squeaky-voiced woman.
I love Firefly, but I just can’t get into Buffy and Angel.
Sex and the City. Why was anyone interested in the misadventures of these four vapid twits and their ridiculously overpriced shoes?
The Mentalist. Oh, look, it’s Psych without the humor! Which is the point of Psych!
My Name is Earl, I’ve tried to watch it a couple times. It’s painful.
The Office, boring.
The Sopranos, dull.
30 Rock, I’ve tried because I like Tina Fey but the obnoxiousness of Jane Krakowski and Tracy Morgan cancel her out many times over. I usually turn it off when they show up onscreen.
Sex and the City, it makes me want to kill people. Specifically 4 women. 4 very shallow women.
I agree with Friends and 30 Rock. Oh, and I guess Sex and the City, but I’m a guy, so I’m not supposed to like it anyway. Everybody Loves Raymond is another one that gets on my nerves. I like most of the other ones mentioned here. Until the Straight Dope, I never realized Seinfeld was such a polarizing sitcom.