Aspie is used to refer to individuals on the Autism spectrum, formerly diagnosed as having Asperger’s syndrome. I first heard the term ‘Aspie’ referred by parents of children with Asperger syndrome. The parents who used this term were very active in the Autism community and never intended for the term to be used as an insult. But some individuals seem to think of the term ‘Aspie’ as an insulting term.
Personally, I don’t find it offensive, and the people I know personally on the autism specturm publically refer to themselves as Aspie.
There’s also the term ‘spergy’ which derives from Aspergers. Spergy simply refers to somebody whose actions are similar to someone with Aspergers. They may be on the spectrum, think they are on the autism spectrum, or simply are insufferable and use an existing medical condition as an excuse. Some individuals have taken exeption to this term and I wonder if people feel the same hair trigger sensitivity when people use adjectives like ‘psycho’ ‘nympho’ ‘manic’ etc.