Has anyone heard of this? It is a drug for heart conditions called “Tardil”.
I found a drug named Cardizem and another reference to Diltiazem, but my friend insists these are not the same. If anyone can please help me search for information I would be profoundly grateful.
This drug is being taken in conjunction with treatment for a coronary thrombosis. “Tardil” may be a foreign trade name for this compound. I have found this quote:
"Doctors sometimes prescribe Cardizem for loss of circulation in the fingers and toes (Raynaud’s Syndrome), for involuntary movements (tardive dyskinesia), and to prevent heart attack.
Tiazac and Dilacor XR are used in the treatment of high blood pressure and chronic stable angina. They may be taken alone or combined with other blood pressure medications."
This seems to indicate a strong relation to the patient’s condition as described to me. However it is insisted that this is not the drug in question. Ergo, I am hoping that anyone might have data on “Tardil”. It is being described to me as a “two phase sleeping drug”.
Again, any help would be deeply appreciated.
IANAD, but according to my 1999 edition of the Physician’s Desk Reference, diltiazem hydrochloride is the generic name of Cardizem, which is a drug for people with high blood pressure and angina (severe chest pain). I can’t find a listing for a drug named “Tardil”, but I don’t think that Cardizem can be it if you’re looking for a sleeping pill.
Thanks for responding, GilaB. Evidently Tardil is a trade name for a “two phase sleeping pill” made in Russia. I’ve been able to find a Russian pharmacological search engine, but I cannot read Cyrillic characters. Sigh!
Any Russian speaking people out there?
Zenster, if you remind me via e-mail (available at the bottom of this post), I will be happy to look this up on Micromedex. It’s a HUGE database of virtually every known drug, but it’s a pay service, and I don’t have it at home.
Robin
Bless you, MsRobyn. (50% cooler than ordinary Robins!) You have my deepest gratitude.
MsRobyn, if you see this before your email, please continue to work on this link. It appears to be the item in question. The manufacturer is Egis Pharmaceuticals, maybe out of Hungary. I’ll email this to you as well. Thanks for your help.
from http://chrom.tutms.tut.ac.jp/JINNO/DRUGDATA/00alphabet.html
Amobarbital
Physical Properties
Molecular Formula : C11H 18N2O3
Molecular weight : 226.28
Chemical name : 5-ethyl-5-isopentylbarbituric acid
properties : White crystal or crystalline powder. Non smell. Taste is slightly bitter.
melting point : 156-159c
pH : 5.0-6.0
log P : 2.07 ( Experimentally determined value ) 2.11 ( Calculated value )
Ionization Constant pKa : 7.8
Solubility -Acetone, Ethanol , Ether : easily soluble
Water , Chloroform : hardly soluble
Oral administration / 1day : 100-300mg
Drug Activity Classification : Hypnotic
Glutethimid
Physical Properties
Molecular Formula : C13H 15NO2
Molecular weight : 217.27
Chemical name : 2-ethyl-2-phenylglutarimide
properties : White crystalline powder. Non smell. Taste is slightly bitter.
melting point : 83-88c
log P : 1.90 ( Experimentally determined value ) 1.89 ( Calculated value )
Ionization Constant pKa : 9.2
Solubility -Ethanol, Chloroform, Ether : easily soluble
Water : hardly soluble
Oral administration / 1day : 250-500mg
Drug Activity Classification : Hypnotic
Promethazine
Physical Properties
Molecular Formula : C17H 20N2S
Molecular weight : 284.42
Chemical name : N-(2-dimethylamino-n-propyl)phenothiazine
properties : powder. Non smell.
log P : 4.65 ( Calculated value )
Ionization Constant pKa : 9.1
Oral administration / 1day : 25-200mg
Drug Activity Classification : Antiparkinsonian