The US military, Easter Bunny, April Fool, Cupid, Baby New Year, and some wiener dog somehow associated with Hallowe’en attempt to kill Santa in the Fairly Odd Parents ‘Christmas Every Day’ episode.
The Anti-Christmas League in the DCU Infinite Holiday Special. But that was just Blitzen playing a prank on the old man.
And, of course, Jesus himself tried to kill Santa in the very first little South Park Short (strong language warning).
thwartme
The Postman in Olive the Other Reindeer. He has a pretty good reason for it, too. 
John Lithgow in Santa Clause: The Movie wants to eliminate Santa (though I don’t think he want to kill him).
Me.
But I’m not supposed to discuss it, on advice of Legal Counsel.
Well, the Devil is Santa’s nemesis in the Mexican movie Santa Claus that I saw as a kid (and was spoofed by MST3K, though I never saw that).
I don’t know if it’s ever made clear who is shooting at Santa in the Movie-within-a-movie “The Night the Reindeer Died” in Scrooged (with Lee Majors obviously trying to be the Six Million Dollar Man without saying so), but anyone who fires a missile at Santa (“Incoming!”) is up to no good.
And who could forget Harlan Ellison’s “Santa Clause vs. S.P.I.D.E.R.”
The cops, in Weird Al’s gory and extra-gory version of Twas the Night Santa Went Crazy.
I must say I am also proud of the Sluggites response to this thread. Of course with the thread title I had assumed the thread was going to be about Bun-Bun.
Upon examination of the evidence and the condition of his roof, it has been determined that Scott Calvin was negligent in failing to provide a safe working environment for Mr. S. Claus, especially considering that Mr. Calvin had a young boy in his apartment at the time and should have made a good faith attempt to clear the snow from Mr. Claus’s work area, resulting in a work-related slip-and-fall incident which was the root cause of Mr. Claus’s death.
Didn’t the Ewoks once suck the joy right out of Christmas? If that didn’t come close to killing Santa Claus I don’t know what would.
Lobo didn’t try. Lobo succeeded.
Multi-Santa in the The Tick’s special.
I opened this thread to refer to this, as (by marvelous coincidence) I just watched the MST3K version Sat night. Excellent episode. Bizarre movie.
Where did you get it? I need to fill in my Lost Episodes.
I really wanna see The Sword and the Dragon one. I grew up on that flick.
Santa figured into the plot of the SNES role-playing game Secret of Mana. I don’t remember the exact circumstance, but I think he was bewitched and turned into a monster that you had to fight, before being restored to his normal self.
Terrorists try to kill Santa, but Lee Majors saves him in the “The Night the Reindeer Died” - a ficticious movie from “Scrooged”.
msmith537, look up to post #25.
But don’t do it until Cal looks up at post #18.
The Winter Warlock also is a nemesis in that special, until Santa melts his icy heart by giving him a present.