Buffy: Oh, uh, actually, I need some help. I’m looking for this guy. Bleach-blonde hair, leather jacket, British accent? Kind of sallow, but in a hot way?
Bouncer: Yeah, yeah, I know the guy. Billy Idol wannabe?
Buffy: Actually, Billy Idol stole his look from—never mind. Has he been here?
You’ve reminded me of one, Zamboni - the Three Nerds are discussing their surveillance van that they’ve fixed up:
Warren: She’s ready.
Jonathan: Sweet. Run me through it.
Warren: Ah. We got nine high-resolution surveillance cameras hooked in, super-wide angle, infrared, auto-iris, plus six types of audio matrix monitoring… that’s filtered through a dual quad DVS system, and a…
Jonathan: Yeah, yeah, fine, just tell me. Are you sure with all of this stuff that we’ll be able to watch Buffy without her noticing us?
Warren: Absolutely. I mean, she’ll never even know- w-what the hell is that?
Andrew: Death Star, dude! Wicked, huh?
Jonathan: Thermal exhaust port’s above the main port, numb-nuts.
Andrew: For your information, I’m using the Empire’s revised designs from Return of the Jedi.
Jonathan: That’s a flawed design!
My favorite line from the entire series, boldfaced below (the unbolded lines are just the setup - they’re discussing werewolves).
From Phases
There’s an exchange between Buffy and Spike. She crosses paths with him and demands to know what he’s up to … in five words.
[counting on his fingers]“Out. For. A. Walk.”
“Bitch.”
I know it’s a stretch, but this always made me think that maybe Spike enjoyed old episodes of SNL.
Shared on my Facebook in honor of the 15th anniversary of Welcome to the Hellmouth (15 years, y’all!!!):
When I’m with a boy I like, it’s hard for me to say anything cool, or-or witty - or at all. I-I can usually make a few vowel sounds, and then I have to go away. ~Willow Rosenberg
Oh yeah, then there was all the time Spike spent watching “Passions.” 
His brief conversation with Joyce about Passions is one of my favorite moments. It’s part of the reason he doesn’t kill Joyce. Everyone, even demon vampires, loves Joyce.
This is one of my favorites from Spike. I had to look up the whole thing.
Let me just say that this thread proves that Buffy was one of the most awesome shows ever on TV.
As to pop-culture references, I got nuthin’.
But my favorite line is (Xander) “There’s something you don’t see every day…unless you’re us.”
Buffybot: If you want her to be exactly she’ll never be exactly I know the only really real Buffy is really Buffy and she’s gone who?
Spike: Oh, poor Watcher. Did your life pass before your eyes? Cup of tea, cup of tea, almost got shagged, cup of tea?
Not exactly “pop” culture, but…
…after Buffy reminds everyone going to the tower to fight Glory that they know their jobs, that if the ritual starts, everyone dies, and she’ll kill anyone of them that comes near Dawn.
Uncomfortable pause, and then Spike says, “Well, not exactly the St. Crispin’s Day speech, was it?”
Giles says in agreement, “We few, we happy few…”
And Spike replies, “We band of buggered.”
Does Angel count?
Illyria (beating the stuffing out of Spike while the group tests her strength; scene ends with his face on the floor and her boot on his head): I wish to keep this one as my pet.
It’s worth pointing out that the thread is about your favorite pop-culture reference from Buffy, not just your favorite quote from Buffy
Noticed that. Too late. Sorry. :smack:
Spike (to Adam): “I get why all the demons all fall in line with you. You’re like Tony Robbins. If he was a big, scary, Frankenstein-looking… You’re exactly like Tony Robbins”
Weetabix, which Spike uses to crumble in his blood to “give it texture”.
Went to Ireland one year and there were mini boxes of Weetabix in the hotel breakfast buffet. I went over the moon when I saw that, because as an American, I wasn’t sure if Weetabix was a real cereal or not. Glad to learn that it was.
Also liked Buffy’s pun from Season 3 that Faith wouldn’t be on the cover of Sanity Fair.
Spike, in his first appearance: “If every vampire that said he was at the crucifixion was actually there, it would’ve been like Woodstock. I was actually at Woodstock. That was a weird gig… I fed off of a flower person and spent the next six hours watching my hand move.”
There’s a bit in the last season where I think Giles, Spike & Andrew are playing D&D. One of them rounds a corner to come face to face with ‘Trogdor… the Burninator!’.
SPIKE: Come up against this Slayer yet?
ANGEL: She’s cute. Not too bright, though. Gave the puppy dog ‘I’m all tortured’ act. Keeps her off my back when I feed! (laughs)
SPIKE: People still fall for that Anne Rice routine. What a world!
A few lines later, he yells at Angel in disgust that “You were my Yoda!”
I couldn’t help noticing that Spike’s appearance, and Giles’ backstory, both bore a striking resemblance to John Constantine.
In an early episode, Buffy was having a crisis, and Cordelia told her to get a grip, and “spank your inner moppet”.