Vittorio De Sica and Marcello Mastroianni
Jenna Jameson and Jay Grdina
John Ford and John Wayne
David Zucker and Leslie Nielsen
Billy Wilder and Jack Lemmon
John Ford and John Wayne.
Edit: Ninja’d with the latter by kunilou.
Edit2: Werner Herzog and Klaus Kinski.
Terry Gilliam/Katherine Helmond
Coens / Clooney
Scorsese & DeNiro & Pesci
Coen Brothers & John Goodman
Hitchcock & Cary Grant or Jimmy Stewart
Clint Eastwood/Sergio Leone
Sam Jackson/Quentin Tarantino
Mel Brooks & Gene Wilder or Madeline Kahn or Cloris Leachman
Tarantino & Samuel L. Jackson or Harvey Keitel
William Wyler & Audrey Hepburn: *Roman Holiday, The Children’s Hour & How to Steal a Million *
George Cukor & Katherine Hepburn
Wes Anderson & Bill F*cking Murray
Tim Burton & Johnny Depp & Helena Bonham Carter
Frank Capra & Jimmy Stewart of course
Francis Ford Coppola & [del]Nick Cage[/del] (I joke) Robert Duvall
Roger Corman & Vincent Price, I know it is all low budget schlock but it is great low budget schlock.
John Ford & {John Wayne, Victor McLaglen & Maureen O’Hara together} or Henry Fonda or John Carradine
Jim Henson & [del]Kermit the Frog[/del] & Frank Oz 
Ivan Reitman & Bill F*cking Murray
Edgar Wright & {Simon Pegg & Nick Frost}
Woody Allen and Diane Keaton
Ingmar Bergman and Liv Ullman, Gunnar Bjornstrand, Harriet Andersson, Max von Sydow, Bibi Andersson, Ingrid Thulin, and Erland Josephson
Richard Lester/The Beatles
Jon Favreau/Robert Downey Jr.
QuentinTarantino and Samuel Jackson.
Ching Siu-Tung and Jet Li
Philippe de Broca and Jean-Paul Belmondo
Hideo Gosha and Tatsuya Nakadai
Tod Browning and Lon Chaney, Sr.
Seijun Suzuki and Jô Shishido
Paul Morrissey and Udo Kier
Ishirô Honda and Haruo Nakajima