Leela: So, how was the universe created?
Nibbler: [unintelligible babbling in the Nibblonian language]
Leela: And the meaning of existence?
Nibbler: [more Nibblonian babbling]
Leela: So every religion is wrong.
Something someone posted recently made me recall this one, which sounded like my response to the situation in my head:
Amy: Why don’t you try homeopathic remedies? Like some herbal tea, or echinacea?
Farnsworth: Or a big fat placebo! It’s all the same crap!
Which ranks right up there with the robot truck looking for scientists:
Person: I have a degree in homeopathic medicine!
Robot: You have a degree in baloney! [sprays him with water cannon]
My personal favorite is when Dr. Zoidberg goes insane at a gym, and interrupts a pre-natal water aerobics class.
Mothers: “AAAIIIIIEEE!” (plopping, crying newborns)
Someone: Is there a doctor in the house?"
Zoidberg, gibbering: I’m a doctor!
Mothers: AAAAIIIIEEEE! (more plopping)
Dr. Zoidberg at a horse race:
“No fair! You changed the outcome by measuring it.”
I felt so pretentious when I the only one of my buddies to chuckle.
Racetrack PA announcer: And the winner is number three, in a quantum finish.
Professor Farnsworth: No fair! You changed the outcome by measuring it!
(on preview: damn, too late!)
Marv Albert: Ladies and gentlemen, something very strange has just occurred in this basketball match between space clowns and atomic monsters.
Fry: Wow! That guy makes Speedy Gonzalez look like Regular Gonzalez!
When Bender gets to meet his favourite TV chef Elzar:
“Oh this is the greatest nanosecond of my life. No, this one is - no, this one. Wait…that one was slightly worse. Ah, so far so good on this one.”
And lets not forget Elzar himself:
“Folks tell the neighbours to watch your mouth 'cause your tastebuds are going on vacation.”
I wish I could cook like that 
I believe Someone was the moon farmer, and Someone Else was Fry.
You remember the moon farmer? He had three beautiful robot daughters: Trixie, Dixie, and The Crushinator 5000.
Well, actually, they were LuluBell 7, Daisy May 128K and The Crushinator.
Sadly, I didn’t even have to look that up.
Al Gore “I have ridden the mighty moon worm!”
Fry “Where’s the bathroom?”
Bender “The what room?”
Fry “The bathroom.”
Bender “The bathwhat?”
Fry “The bathroom.”
Bender “The whatwhat?”
TREES DOWN!
“Fry crack corn and I don’t care, Leela cracks corn and I don’t care, Bender cracks corn and he is great. Take that you stupid corn”
Cheese it!!
Zapp Brannigan: “The spirit is willing, but the flesh is bruised and spongy.”
Nixon’s Head: “I’ll sell our children’s organs to zoos for meat, and go into people’s houses at night and wreck up the place!”
Professor: “Get off my property!”
Hippie: “You can’t own property man!”
Professor: “Yes I can, because I’m not a penniless hippie!”
Llrr, after eating said hippie: “Whoa, my hands are huge! They can touch anything except themselves.” (touches hands together) “Oh, wait…”
“My hands can touch anything but themselves!” (touches hands together) “Oh, wait…”
There’s a very similar line which might be from The Simpsons:
“Why do they call them ‘fingers’? They don’t ‘fing’.” (bends fingers) “Oh, wait…”
Come to think of it–Is the actor who does the King of Omicron Pesei 8 the same as the one who does Otto the bus driver?
Fry: You mean we can never catch up to him? Even if we rub the engine with cheetah blood?
From an episode of the Scary Door: Why should I believe you? You’re Hitler!
Bender: Saw it coming.
Zapp Brannigan: Men, you’re lucky men. Soon you’ll all be fighting for your planet. Many of you will be dying for your planet. A few of you will be forced through a fine mesh screen for your planet. They will be the luckiest of all.
Lrrr is played by Maurice LaMarche (of Pinky and the Brain fame) and Otto is voiced by Harry Shearer.
Prof. Farnsworth: Aahh, so that’s what life would be like if I had invented the Finglonger. A man can dream, though. A man can dream!
Maurice LaMarche is the voice of the King of Omicron Persei 8; Harry Shearer is the voice of Otto the bus driver. It troubles me that I knew this without looking it up.
Edit: I am less troubled now, since I see that someone else knew the answer a minute before I did.
My favorite line comes from one of the “What If” episodes, where Fry never went to the future. He got to meet the guy who invented D&D who said, “It’s a…(rolls dice)…pleasure to meet you!”
Morbo, Nixon & the Proffessor get the best lines!
I like when Professor Farnsworth says that dark matter is so heavy that one pound weighs almost 10,000 pounds.
Oh sure, everyone wants to save Hitler’s brain. But when you want to put it in the body of a shark, suddenly you’ve gone too far.
You are entering the realm which is unusual. Maybe it’s magic or contains some kind of monster…The second one.