How about Ctrl+Alt+Del? That’s one I read every time it’s new.
I also read Shortpacked! regularly and saw David “Walky” Willis speak at AnimeFest in 2010, right before he unveiled Dumbing of Age. I had a hard time getting my son to sit through the lecture, though.
Sinfest is fun when I’m not at work. I’m pretty sure they’d block the URL. If they don’t block Least I Could Do, they probably should. That’s for reading at home, too.
There are a few I miss:
Turn Signals on a Land Raider, my favorite Warhammer 40,000-themed comic ended, but you can still read from the archives.
The author of Fallen Angels Used Books is so buried in her studies that she’ll likely never come back to it.
Josh Lesnick used to do a strip called Wendy, but he’s expanded since then, and Wendy and her friends will show up occasionally in a DeviantArt project or his newer work, like Girly.