It’s not sundown yet, so Shabbat hasn’t started. I take most every serotonin reuptake inhibitor on the market. It will be a small edible. Your expert opinion, sil vous plait?
I take Venlaflaxine (brand name, Effexor); it doesn’t interfere with marijuana use.
ETA: Not a doctor or any sort of expert.
It’s unlikely any real doctor will comment on a specific real world scenario on a message board.
I’m not a doctor. I have taken different SSRIs, and I’ve taken edibles. What exactly, is your question? I don’t agree with THC—it makes me vomit and feel very unpleasant. You might be different.
I doubt it will kill you. Have you tried Marijuana or THC containing products before?
Yeesh. In my youth I smoked my share of marijuana. It agreed with me fine. I am concerned there will negative interactions.
Pfffft.
Don’t do it, then
I am doctor, but this is not a medical opinion.
Especially for a novice or first time user, take a SMALL dose. No more than 5 mg in my opinion. Also keep in mind that you don’t have to be stoned to feel better on it.
Here’s a concise (somewhat relevant) link on edibles: https://www.cmaj.ca/content/192/7/E162
Have you no sense of adventure? 
It’s little. I probably won’t even feel it. 
The problem with primary mood altering drugs is that when they wear off, there’s usually a depressive rebound. This tends to be worse for people who already have depressive symptoms. The recommendation by most mental health professionals is that to successfully treat depressive symptoms, it’s best to have all primary mood altering drugs (alcohol, THC, opioids, benzos, cocaine, etc.) out of one’s system over the course of treatment.
Most patients resist this advice, however.
And Telemark, you’ve been here as long as I, you should have noticed by now that I and lots of other docs answer these sorts of questions all the time. 
I am not a doctor, but a lot of regular users of edibles have offered this advice. Because the effect of edibles takes a long time to notice – much longer than if you smoke it – it’s easy to take more than you’d have wanted to, and there’s no way to reduce the dose once you’ve eaten it.
Please explain that alien concept. 
Really, I’ve been warned thoroughly about dosage and modern dope. If I can stretch a single edible into two nights watching Match Game 75 while stoned my nostalgia will be complete.
It might take an hour or so before it kicks in, so make sure you take it early enough that you don’t end up falling asleep too early. 