“Is it…?”
“Can it be…?”
“It is… it’s the lost city of Altanta!”
Futurama
“Badgers? We don’t need no stinkin’ badgers.”
UHF
“Can’t we all just get along?”
Mars Attacks
Got any more?
Any joke on a sitcom where two people are talking and one of them is talking about something innocuous, like going for a walk or baking a pie or something, and the other thinks they are talking about sex with children or murdering old ladies or something.
Hate that, and it’s used so freakin’ often. Predictable, and even if it weren’t it’s still not funny.
And, this choice may not be liked but I saw this one coming a mile away.
From Monty Python and the Holy Grail
“What is your favorite color?”
“Blue- I mean gre- AAAAAAAAAGH!”
The whole “Santa Claus, the Tooth Fairy, and a well-adjusted lesbian are standing on a street corner” joke from Chasing Amy. I’d already heard it at least five years before seeing the movie, probably longer, and at the time it didn’t even warrant a chuckle from me. Seeing it up on screen dragged out to 10 minutes in the telling, including diagrams, was just the first sign that I was going to hate this movie.
So two friends walk into a bar…
Every joke in Austin Powers in Goldmember.
Yep, but it’s forgiveable IMHO because they managed to pull off a pun based on that famous line, and actually set it up in enough detail that the punchline made sense. A dumb joke; a noble cause. Or something.
You realize you just invalidated the existence of Three’s Company in one fell swoop?
Oh wait, that’s a good thing. 
The joke is;
Two men walked into a bar
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The third one ducked.
I told that oldie a couple of weeks ago to a couple of college kids and they just did not get it. What is this world coming to?
My second favorite:
The toothless termite walked into a bar and said:>>>>>>
“is the bar tender here?”
Back to the OP, it’s not usually jokes themselves, but the person telling it. Have you ever had to sit and listen to someone giggle and snort at their own cleverness as they slooooooowly make their way to the punchline? And it’s usually something along the lines of “what’s black and white and red all over” (to provide a target-rich example).
The great tragedy is that a sufficient amount of alcohol turns me into one of those people 
The Daily Worker?
A zebra shot with a bazooka.
Wouldn’t that be black and white and red and all over?
I have a friend who simply cannot tell a joke. He gets jokes just fine. He just can’t tell one to save his life. I am subjected to the aforementioned 10 minute painfest at least once a week as my friend struggles laboriously toward a punch line which he absolutely is guaranteed to fuck up royally. It’s sad.
It’s coming right for us!
I remember hearing this joke on a really bad sitcom called The Last Resort sometime in the mid-70s.
A bay skunk w/diaper rash?
The worst of these are people who actually start with the punchline. “Do you know the one where the chicken tried to get to the other side of the road? No? Let me tell you…”
The live-action Inspector Gadget had this one joke in it that was set up over the course of the whole movie. They created an evil robot Inspector Gadget for him to battle. By the end of the movie, the good Gadget won, and all that was left of the robot was his severed head.
The good Gadget picked him up and offered forgiveness, but the evil Gadget kept trying to convince him that they could control the world together etc etc
The good Gadget decides enough is enough. He looks into the camera, sighs, and says…
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…“You should have quit while you were a head.”
In Goldmember , as soon as they introduced a character named Roboto, I immediately knew the punchline that would come 10 minutes later (“Domo Arigato, Mr. Roboto”).
Every joke on “Tough Crowd”. One of the comedians said it best when he slamed one of the others by saying, “You are really desparated to get that pre-written ad-lib out aren’t you?”
Fagjunk Theology: Not just for sodomite propagandists anymore.
I read the title and was all set to come in here and wow you all with my “Three nuns walk into a bar” joke.
Poop.
Howz about “comic relief” in any sitcom? Something sad was just said by a main character. 5…4…3…2…<comic relief!! laugh track!!> Will & Grace is the worst offender.