In Moshi, Tanzania I came across a little restaurant called El Rancho.
An Indian restaurant: http://kiliweb.com/restaurants.html
Then of course the bar in the town of Gay, Michigan is called…
A couple from HK. A clothing chain called WANKO and a car dealership (Nissan, I think) called Honest Motors.
When I first got to this town I was driving around aimlessly just to get my bearings on how and where everything is here and I came across a business that imo could not have been worse named. It is called Miss Carrie’s Day Care.
Every time I drive by it now I just wince.
Buffalo Sanitary Wipers
It’s a commercial laundry.
In Dubuque, IA we have Butt’s Florist. 
hehehhe…I said butt.
Not as funny or suggestive as some of the others, but I have a picture of a storefront in London for a shop called Fish n Things. The funny thing about it is that, looking in the window, they’re not selling fish, or fishing gear. I have no idea what the name has to do with the business.
We have the obligatory Phuket Thai restaurant which made my son’s eyes bug out the first time he saw it and a mobile BBQ guy called Pete whose motto is emblazoned across his truck - “You don’t need teeth to eat Pete’s Meat”.
But one of our family favs is outside Canton, GA called the “Fast and Easy”. It’s a convenience store but the windows are darkened and they do the online video gambling plus there seems to be some awfully seedy women in there. . .
There’s a “Rock Bottom Liquors” in Dover, NJ. I’m sure they’re talking about their low prices, but it reminds me of a smelly, homeless alcoholic stumbling in to shoplift a jar of corn whiskey.
Chinese Restaurant near Philly (USA): Hung Fat.
Oops. Forgot the ice cream one.
Ice Cream joint:
www.icecream.cone
Ooh, just remembered another local one. Not as bad a name, but still: aren’t you creeped the hell out by a store called Unka Bubby’s Toons?
It was, apparently, a music store, not a pedophile’s kiddy-trap, but I always crossed the street to avoid it anyways. And so did other people too: it went out of business fast.
Daniel
Hey, I want to see the funny sign. This link is broken. 
I live near Teter Prosthetics.
Cracks me up.
There’s a corner shop along the road west out of Hammersmith in London called BOOTY. I keep meaning to take a photo of it but I haven’t got round to that yet.
Somewhere on the road between Chicago and New York, maybe Cleveland, there is a gas station called Pump and Dribble.
I had to take a picture of the sign.
There was a bar on the corner by my apartment once called Sit and Sip, but it was such a dive, we called it the Slouch and Slurp.
I don’t know whether this is in the category of most appropriate or least appropriate, but there used to be a liquor store called Belcher’s near Lexington KY.
On U.S. 70 between Raleigh and Goldboro the is a car dealer ship called Sadisco.
The Omahans play:
Dung Billiards
I’ve seen various hair salons named Bushwacker*. For, numerous reasons, I just don’t see that as a good name, but at least one of the companies has been in business for over 30 years. On the naïve side, I just wouldn’t trust my hair to a place with such a name (and judging by the Pit threads, I’m not the only one particular about my hair). 
*Alternate spelling is Bushwhacker.