I did actually remap my movement keys in WoW to QWES - basically, I swapped the turn keys with the strafe keys: Q & E are now turn left/right and A & D are strafe left/right. I just realized I was a bit inaccurate regarding City of Heroes in my OP - CoH also used Q/E for left/right turning. I got used to it there; during the year I played CoH I hardly played WoW for the first 6 months and then cancelled my WoW sub for the last 6. CoH’s shutdown coincided with the release of WoW’s Mists of Pandaria expansion, which I’d already intended to return for. So when I came back to WoW I realized I preferred QWES over WASD and so I remapped my keys accordingly.
I keep my left/right turning keys because I pretty much play solo. I’m primarily a mouse-turner, but I also use my mouse hand to take a drink and being able to keep steering with my left hand lets me keep moving while I’m taking a drink with my right. I’ve also developed a technique combining mouse and keyboard turning that is useful to me in a few specific situations.
But I like keeping my forward movement on the W key, because I have my characters’ main rotation abilities centered around the 3 key. So when I engage an enemy it’s a simple matter to slide my fingers pretty much straight up from QWE to 234.
Giving it more thought, I guess it’s not so much a matter of which specific keys are used as it is the combination of the physical controls and the way the game’s physics engine handles movement. Which I guess boils down to “feel”. In some games, like WoW and CoH (and to a lesser degree, LotRO and Rift), my character almost immediately felt like an extension/projection of myself into the game world. Other games, like TERA and Wizardry, felt more like I was trying to remote-control a puppet. Another contrast is CoH vs. Champions Online. CO was created by the same main group of people who created CoH, and uses virtually the same movement controls, but CO uses a much newer version of the same engine. And, well, it “feels” completely wrong to me.