Billie Holiday and Lester Young
Humphrey Bogart and Lauren Bacall
Spencer Tracy and Katherine Hepburn
Carol and Ed Emshwiller. Carol was an extremely well-regarded SF author;* Ed started out as an SF illustrator, but then became one of the top video artists in the early days of the format.
*She died last weekend, BTW
Gertrude Stein and Alice B. Toklas
No mention yet of the Schumanns (Robert & Clara) or the Brownings (Robert & ELizabeth Barrett)?
Ooo, good one! Love their stuff.
https://www.google.com/search?hl=en&tbm=isch&sa=1&ei=OldbXOihH4ae_QbS46qYCA&q=charles+ray+eames+furniture&oq=charles+ray+eames+furniture&gs_l=img.3..0j0i8i30.8248.9187..9405...0.0..0.75.683.10......1....1..gws-wiz-img.......0i30j0i24.XnY744xXuc4
https://www.google.com/search?hl=en&tbm=isch&sa=1&ei=VFdbXO3JIYb5_AbDlI34Dw&q=charles+and+ray+eames+architecture&oq=charles+ray+eames+arch&gs_l=img.3.0.0i8i30.5786.6138..7101...0.0..0.77.214.3......1....1..gws-wiz-img.r7ogLnQ9zzE
Mickey and Minnie Mouse.
Yes!
Sonny and Cher.
The Captain and Tennille.
Mouth and Macneal.
Ted Hughes and Sylvia Plath.
John Lennon and Yoko Ono.
I think the OP expects that both would have talent.
Robert and Sonia Delaunay.
Mary Pickford and Douglas Fairbanks
Frédéric Chopin and George Sand (not married, but kind of a friends with benefits type of deal)
Natalie Wood and Robert Wagner ( … well, perhaps not a “happy” couple).
Mary & Percy Shelly
It’s “Shelley.”
“It’s FRONK-en-steen.”
Paul and Linda
Pete Townshend and Rachel Fuller
Erik and Lyle Menendez
Man Ray and Lee Miller
Charles Laughton and Elsa Lanchester
Akira Kurosawa and Toshiro Mifune.
Sarah Brightman and Andrew Lloyd Webber.