I’m having trouble getting my head around why you excluded Harold and Kumar, furt. Getting to White Castle symbolizes coming of age for both of them. Harold gets the courage to tell off his supervisors and ask out Maria, and Kumar realizes he really wants to be a doctor. When they turned down going to the weiner shack or whatever they rejected taking the easy path/doing what was expected of them. You could also say that place also played on the homoerotic undertones between Goldstein and Rosenberg.
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Also, lots of folks see a theme of characters eating oranges and later being killed or dying, which could have all sorts of fun potential deep discussions. One fun path I’ve taken down this train of thought is that the oranges could refer to the Fruit of Knowledge in the Garden of Eden, the eating of which lead to Adam and Eve being banished from the Garden of Eden and doomed to mortality.
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I remember from the news around the time of the '95 Kobe earthquake that oranges are offered as food for the dead in Japanese culture.