The Philadelphia Story.
“You have a lot to learn, and I hope you never learn it.”
Butch Cassidy and the Sundance Kid
“I don’t need a compass to show me the way the wind shines.”
“Well, nobody’s perfect!” 
Mystery Men
Some Like it Hot (hey, if I can get one, I’ll take it)
“It’s all in the reflexes”
Fiddler on the Roof.
Big Trouble in Little China
“You imbecile! You bloated idiot!”
Maltese Falcon
‘Well, a girl has to have her standards’
Shelley Long in Outrageous Fortune.
“HOW many Romans?”
Trading Places
Tombstone.
Life of Brian.
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“Did you just say ‘yutes’?”
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“All right, pussy, pussy, pussy! Come on in pussy lovers! Here at the Titty Twister we’re slashing pussy in half! Give us an offer on our vast selection of pussy, this is a pussy blow out! All right, we got white pussy, black pussy, Spanish pussy, yellow pussy, we got hot pussy, cold pussy, we got wet pussy, we got [sniffs] smelly pussy, we got hairy pussy, bloody pussy, we got snappin’ pussy, we got silk pussy, velvet pussy, Naugahyde pussy, we even got horse pussy, dog pussy, chicken pussy! Come on, you want pussy, come on in, pussy lovers! If we don’t got it, you don’t want it! Come on in, pussy lovers!”
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“We have an expression in prize fighting: “Everyone has a plan until they’ve been hit.” Well my friend, you’ve just been hit. The getting up is up to you.”
Sordid Lives
And I’d just like to note, for Sampiro’s amusement, that his post was positioned so that I could see that punch line but the username was cut off by the top of the monitor, and I still instantly knew who’d posted it…
I was going to use “Well, nobody’s perfect!” but someone stole it.
sigh
Cheech Marin in From Dusk 'til Dawn.
“It would have to be made of solid nuclear matter. It would sink of its own weight to the center of this planet!”
“The cuckoo clock”
My Cousin Vinny
“I dated his wife for a while.”
Real Genius
“Who’s got you?”
Forbidden Planet
“Like I always say - put a fox in the henhouse and he’ll have chicken for dinner every time.”
Oh shit, I totally know this one. It’s Michael Douglas saying it… is it The Ghost and the Darkness?