It’s been long mentioned in the media that some substances like methamphetamines and MDMA are neurotoxic (dopamine and serotonin neurons resp.). With Ecstasy (MDMA), there is some controversy over the extent of such toxicity. With meth, it seems well-established. Ricaurte, probably the world’s pre-eminent researcher on Ecstasy, says “Everyone in the field has accepted [MDMA] is a neurotoxin. I think those [dissenting] arguments have to be put in perspective.”.
However, I came across a link to this interesting article. The author spews some rhetoric initially. Later on, however, he writes
For the two claims
- Assay of neurotoxicity, he cites “Assessing Neurotoxicity of Drugs of Abuse(PDF) by J O’Callaghan, NIDA monograph 1993”. The relevant article in this monograph is on pg 188. A scan reveals
**They do find neurotoxicity in mice, however.
*indicating lack of neurotixicity
2) Meth possibly not neurotoxic, “Striatal Dopamine Nerve Terminal markers in Human Chronic Methamphetamine Users by JM Wilson et al, Nature Medicine 2: 699-703 (1996)”. The linked abstract of this cite says, "…levels of DOPA decarboxylase and the vesicular monoamine transporter, known to be reduced in Parkinson’s disease, were normal. This suggests that chronic exposure to methamphetamine does not cause permanent degeneration of striatal dopamine nerve terminals at the doses used by the young subjects in our study…"
Has it been proven one way or the other, since then? Can someone provide the straight dop(amine)?