What shows would you update? What, if any, changes would you make? (tone, setting, perspective, gender-flipping)
Golden Girls, but with all Gay men in their early to mid 50’s.
Blanche character would be a guy who works out at the gym and still has lots of younger boyfriends.
Dorothy character would be a guy who is slightly overweight but a brilliant teacher who can rarely get a date.
Rose character would be the naive guy who had only one lover for 20 years until he died, but has lots of stories about growing up in St. Priapus, Wyoming.
Sophia character would be the oldest guy (75 or so) who once owned the Gay club where they all met 20 years ago.
Set in Miami, they might have an oddball neighbor lady (Betty White) who stops by every once in awhile.
Small Wonder: This time it’s an action-adventure series and V.I.C.I. is a killer robot from the future, played by Summer Glau.
Buck Rogers in the 25th Century: A BSG-style makeover. Twiki remodeled so his head looks less like a penis and fitted with shoulder mounted missile launchers.
The Littlest Hobo: Verne Troyer plays a tramp. Comedic and heart-warming adventures ensue.
The Man From Atlantis. Only we get to visit Atlantis.
Automan. I reckon there’s a lot of potential to upgrade a show about a computer hologram action hero.
Tales of the Gold Monkey. We need a decent period Indiana Jones ripoff on our screens, dammit.
BJ and the Bear. There are few things more timeless than Big Rig trucking and chimpanzees.
But we make BJ McKay a serial killer and Bear is the draw he uses to trick his victims into getting into his truck…
Actually, now that I think about it, BJ and the Bear sounds like a gay porn title.
Can I assume you’re upset that The Sarah Connor Chronicles got canceled? 
I don’t know so much about “re-imagining”, but I’d love to see a remake of The Champions. I say keep the distinctions between the central characters; the reserved sarcastic Brit, an outgoing Yank and a stunning blond in short skirts.
I’d take a Web TV series, “The Guild” and have all the characters play Second Life or something like it instead of WoW or something like it, and have actual sexual relationships between their avatars, who of course look NOTHING like them. Oh, the hijinks when Zaboo shows up at Codex’s door!
I already mentioned this once, but Happy Days as a HBO/Showtime/AMC type dark show. Chuck’s disappearance would finally be addressed.
I agree with Buck Rogers as mentioned above, and Lost in Space would be a good choice, too, now that enough time has passed to forget about the movie.
How 'bout: “Family Ties”, except it’s Right-wing fundie parents with a rebellious ACLU loving kid.
You really could do all sorts of things with “The Six Million Dollar Man” and “The Bionic Woman”. I mean, if you treat cyborg body parts realistically, instead of just giving the characters super-powers.
In particular, a man with steel arms and legs, but a back of flesh and bone, will not be able to lift a car without breaking his back.
The Pretender, except with a budget.
Profit, only even more eviler.
Jeopardy!
But, really put the contestants in perilous situations.
Like the original books did. For example, in one scene Steve Austin was chained near a bomb, and he couldn’t just tear himself free with superhuman strength because while his arm was strong enough, he wasn’t. Even if his arm didn’t rip itself off his shoulder, pulling on a chain wrapped around him strongly enough to break it would also have pulled it through him.
He also couldn’t run at superhuman speeds - his legs could move fast enough, but his human balance system wasn’t up to the job of keeping himself upright if he tried. What he could do is just keep running and running and running at top speed as long as he could stay awake; the legs were doing almost all the work. In one scene he is stranded in a desert with no water and an injured woman, he picks her up (supporting her with the cyborg arm) and runs to shelter and water. By the end of the day-or-so long run (he starts at night) he is semi-delirious from heat and thirst, barely able to keep going - but he’s still moving just as fast as he did when he was rested.
My Two Dads would now have a totally different backstory.
Something like: the female friend of a gay couple asked them to donate sperm, which they both did but without ever finding out whose swimmers won the race. Then the friend is killed in a car accident, and the resultant daughter comes to live with them…?
I’d love to see an update of Eerie, Indiana, reimagined for adult audiences. It’s been eighteen years since Marshall Teller left Eerie, but now he and his wife Fiona (who had a similar background) have returned to the strange place where he spent part of his childhood. Things haven’t gotten any less strange in Eerie, but in fact that turned darker. Marshall’s old friend Simon seems glad to see him, but it’s soon clear that Simon, like the town of Eerie, is trying to hide something…
Love, American Style. Same format as the original, only hardcore.