I have only played a handful of modern video games, but in one of them a radio played a commercial for a Viagra-type product called ENGORGE. It was done straight, but was hilarious, and every time they said ENGORGE, it was done in a loud booming voice with a lot of echo.
I thought it was a commercial you can listen to on the car radio in Grand Theft Auto IV, but I can’t find it in any listing of commercials in the game or anywhere else.
Mass Effect 3 (and maybe the others) also had parody trailers for their “Blasto” series of action films. Imagine a monotone giant jellyfish reciting Arnold-esque lines.
To be more exact, Borderlands 1 DLC: The Secret Armory of General Knoxx. The female assassin you are working with conceals her messages within those ads.