Paxlovid Rebound: How Long to Test Negative Again?

So I first tested positive for COVID on 12/19, a Monday morning, and was put on Paxlovid right away (within 12 hours of first symptoms). That was a Monday, and by Friday evening I was testing negative again. Alas, I was not out of the woods yet; the following Thursday I woke up sneezing nonstop and tested positive again. Still positive as of last night.

So far Tom Scud has escaped infection; I have been isolating in one bedroom with a HEPA filter running, leaving only to grab food from the kitchen or use the bathroom, or maybe to throw in a load of laundry or something (although I have only had enough energy to do that in the past day or two). We are both masking in the house unless we are alone in a room with the door shut. So far it’s worked, but it sure would be nice to feel like we could, say, safely sprawl on the couch and watch Netflix. I am definitely getting stir-crazy after not going further than my front door for nearly 2 weeks.

What have other people’s experiences been with testing negative again after a rebound? When will we know that Tom Scud is out of the woods, assuming he continues to test negative?

For my lovely wife, a negative test on day 6, followed by increased symptoms and a positive on 7, then not negative until 15.

I was positive for 7 days on the initial symptoms and 7 days again on the rebound.

Ugh. Sounds like I probably have at least a few more days to go, then. I might build a fire in the fire pit and sit in the backyard, then, just so I don’t go completely stir-crazy. Luckily it’s not 20 degrees below zero here at the moment.

It took me 10 days post-pax to test fully negative. I started it on day 2 of testing positive (day 3 of feeling awful). We, too, stayed fully separate, masked when in common areas, and did not share a common area at the same time. It sucked (although my SO probably loved being able to play XBox without having me on him to get off his butt).

Update: round 2, day 5 post-positive. Tested negative once again this morning. Hopefully it sticks this time! Still exhausted as all hell, but managed to work a full day. We may do something crazy like sprawl on the couch together and watch Netflix (masked, of course).

This is old now – have you fully recovered? Is Tom Scud okay?

Yep, I am finally back among the living! In the end I missed 2 weeks of work and it took about 3.5 weeks total to feel like myself again. The second round of testing positive also ran 5 days in the end.

All in all, it wasn’t nearly as bad as I feared it might be given my crappy lungs. However, it’s still totally worth avoiding (that was the longest absence from work due to illness of my entire career), and I can’t imagine how bad it might have been if I hadn’t had every vaccine I was eligible for. And miraculously, I didn’t infect anyone else!

Good to hear. I am now at the beginning (paxlovid day 2), and of course hope for a shorter process.

While sick, I have been reading a bit about paxlovid rebound. There also can be rebound after going through COVID without paxlovid. And there does not seem to be any randomized controlled study showing a statistically significant increase in rebound rate after paxlovid, although some very good research physicians think it is probably real.

While the benefit to risk ratio for the vaccines is quite high, I read a recent blood cancer presentation suggesting that, at least for people in my boat, the vaccines aren’t working quite as well for post-omnicron variants. What still is working as before is pavlovid. (This of course isn’t medical advice – I’m just saying not to be sacred of pavlovid if your doc advises it.)