Briefly, the gang is holding an intervention for Christopher. He is resisting. He shouts back at Tony, ‘…look at the way you eat. You will be dead at 50.’
Gandolfini died of a heart attack at 51.
Rewatching the show, he was the glue that held it all together. He was brutish and sensitive. He was genius.
It happens a few other times, too. After Vito slims down, he starts making not very subtle hints that he would be ready to take the big chair if Tony ever has a heart attack. And Christofuh and Tony B. agree that Tony is a heart attack waiting to happen while they are upstate moving a can of peaches.