I love** Tom the Dancing Bug**, a weekly comic.
That is my favorite these days.
Political: Doonesbury
D&D style, all new WoW flavour: Flintlocke
Quirky: Non Sequitur
I would have to recommend:
These, in addtion to Penny Arcade and occasional checks on Ghastly’s Ghastly Comic (which I simply won’t link to… Oh, okay, here , but it’s in no way shape or form safe for work, so don’t say I didn’t warn you.
I used to read Judge Parker a lot too, but that got too mind-numbing after a while.
I’ll second the vote for The Adventures of Dr. McNinja, and also add my own recommendation for The Holy Bibble.
In a slightly less blasphemous tone, The Brick Testament is also well worth checking out.
Perry Bible Fellowship is my favorite. It’s wonderfully surreal, with subtle but often sick humor.
Pure mad, addictive weirdness, fresh every day.
As a nerd, I quite enjoy CTRL-ALT-DEL.
Spamusement has some funny stuff. The main comic is rarely updated these days, but there’s a Guest Strips forum where you’ll run across all manner of weirdness. Each thread is a separate cartoon. Since it’s open to anyone who wants to submit a cartoon, quality is very uneven, but I enjoy it.
Achewood I really like it, but it’s very quirky.
XKCD if you’re at all science/math geeky.
Bob the Angry Flower for a weekly surrealist bit of humor.
A favorite of mine was Franklin Fibbs. Each day the guy would spin an ourageous yarn or boast and then end it with a gag.
But it was just dropped by King syndicate for only reaching 10 actual newspapers.
But many survive and each one you can find on the web is gold.
I like Arlo and Janis. The cartoonist really enjoys his work and knows not to take himself too seriously. And Ludwig is the best cat in comicdom! He’s also the reason I discovered Sluggy Freelance for which I am eternally grateful.
Also, two Lego inspired comics:
Irregular Webcomic
Legostar Galactica
And this one is the best steampunk I’ve ever seen - Girl Genius. It’s probably the winner of which fantasy world I would love to live in.
Also gotta second Sheldon. Barkeater Lake has its moments too.
Jack
http://www.pholph.com/index.php?Strip=1
Warning: Mature content with explicit material: graphic language, sex and violence.
Yeah…all the good juicy stuff!
[Liberty Meadows - Internet Sanctuary](Liberty Meadows)
You beat me to it. It’s the greatest.
Get Fuzzy and Pearls Before Swine are two of my favorites. Shermans Lagoon,Overboard,and One Big Happy round out my top five.
I started to answer the OP, but my post mutated into a gigantic beast that could only be contained by its own thread.