Well, I didn’t know about the Simpsons connections but I figured it was because of the following. (From the Wikipedia article, which does also mention the Simpsons)
The “Isotopes” name was deemed appropriate, since New Mexico has a number of well-known scientific and military facilities dealing with nuclear technology, such as Los Alamos National Laboratory, Sandia National Laboratories, and the Waste Isolation Pilot Project (WIPP), as well as the site of the Trinity test.
London Derrieres (think about it)
Paris Trout
Stockholm Syndromes
Jerusalem Artichokes
Berlin Irvings
Peking Ducks
Sydney Greenstreets
Chile Peppers
This only works as a pun if you spell it as “Londonderry Air.” “London Derrières” is a … single entendre.
Peiping Toms
Macau Roni
Mecca Nickels
Seoul Train
Seoul Survivor
Pyongyang Kee Imperialists
Manila Vanilla
Florence Nightingales
Florence Hendersons
New York Cheesecakes
Oslo Down
Moscow Mules
Los Angeles Diablos
“Hamburg Buns” was too obvious? 
I miss the Casper (WY) Ghosts (former minor league baseball team). I still have my hat.
And not too funny, but living here you hear it a lot - the Denver Omelets
The Dubliners sing a song called “The Town I Love So Well” that includes the line “There was music there / in the Derry air,” an inadvertent allusion to flatulence which always cracks me up.
Hear it here: https://www.youtube.com/watch?v=mSZhMo4yTJ0