Gilligan’s unkillable, so he’d be my choice. Remember him vs. the hunter?
Samantha Stevens from Bewitched would be pretty tough to beat. Pair her with Jeannie and you could have a kick-ass female super-duo.
The guys from Big Bang Theory would also be a formidable team if something motivated them sufficiently to do it. They’ve already got the costumes, and with their brains they could be a bunch of mad scientists fighting crime with gadgets and nifty toys.
I’m glad I wasn’t the first one to think of this.
Dan from Roseanne makes a great FBI agent, as seen in Red State. He got to shoot Kevin Smith’s wife in the eye. Why is that special? Well, Kevin Smith directed the movie.
Darnell “Crabman” Turner
(Resonse to Red Forman from That 70’s Show)
Didn’t he already play one of the villains in the original Robocop? Or was this some sort of whoosh?
Kidding aside, Tony Nelson is a military officer who went through astronaut training and spends most of his time thinking like a con man who knows how to handle a gun.
sheriff andy taylor,…,crime buster
Uncle Martin with his sidekick Tim. He’ll even throw in a ready-made villain Brennan.
Close - I think he’d be a totally scheeming, self important super-villain wannabe who, though twists of fate and circumstance, always had his nefarious plans end up doing good.
Referencing WKRP earlier, clearly Dr. Johnny Fever would have to be super-hero who never remembered what he did to earn so many awards and accolades.
I rather like the tongue-in-cheek suggestion that Malcom’s dad Hal from Malcolm In the Middle is Walter “Heisenberg” White after being placed in witness protection.
I can also imagine Han from Two Broke Girls having some incredibly awesome side gig (like a cucumber-cool professional troubleshooter) going on, managing the diner as a cover and putting up with Max, Caroline & Oleg partly for the lulz and partly because he knows he’s awesome yet they’re working in his shitty diner and making hipster-tastic cupcakes or whatever it is they do when he’s out making problems go away in style.
Malcolm in the Middle should have done a whole season where they had super powers.
Hooch is crazy.
Robert Barone from Everybody Loves Raymond.
While trying to make an arrest Robert shoots and kills the son of a mafia gang boss, the gang boss puts a hit on the Barone family and Robert goes out for revenge, Punisher style
“I’m gonna tear out your heart and eat it – after touching it to my chin.”
Thanks for sticking that great song in my head. 
Gibbs from Men at Work as an ultra cool Luke Cage style badass…
I’m sure Creed also had some remarkable capabilities, he just couldn’t remember what they were.
Cosmo Kramer(Seinfeld) and his gift of kavorka (although he’d be wise to steer clear of black neighborhoods.)
Daphne Moon (Frasier) with her skill of ESP.
Ed Chigliak (Northern Exposure) possessed some vague magical skills… Elaine would be his sidekick. (or maybe it should be Elaine as the super hero and Ed as sidekick.)
Mr. Haney (Green Acres) could talk anybody into anything.
It was a whoosh. Kurtwood Smith played Clarence Boddicker in the original.
The “alternate ending” to Breaking Bad in the DVD set shows Hal waking up and realizing that Walter’s drug career was “only a dream.”