I don’t know. If this mix is for listening in the ride, that might be like showing an air disaster movie in flight. 
Heh. Reminds me of the time I read the Michael Crichton book Airframe on a trans-Atlantic flight and realized about four hours in why everyone was glaring at me.
From the 90s:
Geggy Tah “Whoever You Are”
Catatonia “Road Rage”
Cake Like “Lorraine’s Car”
Newer:
Gomez “Airstream Driver”
Chromatics “Night Drive”
Hail Social “Get in the Car”
Imogen Heap “Speeding Cars”
Seasonally Appropriate:
Royal Bangs “My Car is Haunted” 
“Roads Girdle the Globe” by XTC
“Rapid Roy (The Stock Car Boy)” by Jim Croce might fit nicely.
Do we want your friend to be wrapping the vechicle around a tree when she misses the curve due to excess speed, BTW? "Cause so far, it looks like we’re trying to kill her dead.
Born to be Wild by Steppenwolf, if no-one’s mentioned it yet.
My favorite:
The Ace by the Red Clay Ramblers
*Black Denim Trousers and Motorcycle Boots *by Edith Piaf (and others).
Survival Car - Fountains Of Wayne
Little Red Hat, from “110 in the Shade.”
Dwight Yoakam - Guitars, Cadillacs and Hillbilly Music
Prefab Sprout - Cars and Girls
Madness - Driving in My Car (don’t think this hass been listed)
XTC - River of Orchids - it’s about the death of the car and motorways turning into ‘rivers’ of flowers. (Hi phungi!)
MiM
Fly Me Courageous- Drivin’ and Cryin’
I can’t drive 55- but I think Sammy should update it to, I can’t drive 75!
Ted Mulry Gang - Jump In My Car (1976)
That’s the original, not the Hassellhoff abomination
Louie Louie, Lou- I is a bit of a jar, as represented and reconfiggered with that Fuckstick, Louis CK’s, Show.
I’ve always thought of it as a cruisin’ in my white leather, Landau, Red and White '76 LTD. Windsor Block.
A few times I thought about starting a thread just like this but thought it wouldn’t last very long. Boy was I wrong.
And I’m glad to see that none of my two choices have been posted yet:
[ul]
[li]“In My Car” - Joe Walsh[/li][li]“Cruisin’ With The Deuce” - Quarterflash[/li][/ul]
My sole recommendation: Automobile, by John Prine.
This song, unlike many of the suggestions, is specifically about the joys of car ownership and driving.
Here is the spoken segment that closes the tune:
mmm
It’s true. I’m a pimp cruisin’ in my Red and White’76 LTD… the L to the Love, the T to the the time, the D to the Down. ‘66 Black and white comin’’ up on my DTL, Comin’ up clean on The HMS.Pass the test, pass the piss, pass the test, pass the pisst, pass the test.
*Black Sunshine *by White Zombie. It kicks ass.
“Love Shack” by the B-52s (“Hop in my Chrysler, it’s as big as a whale, and we’re about to set saiiiiiiiiiiiiil…!”)
“Paradise by the Dashboard Light” by Meat Loaf
Why is there so little mention of my hero, Bruce?
My favorites:
“Racing in the street” (Darkness)
“Wreck on the highway” (should remind your friend to drive carefully) (The River)
“Drive all night” (The River)
“Highway patrolman” (Nebraska)
“Used cars” (Nebraska)
“Open all night” (Nebraska)
I could go on…
And of course also, from Melissa Etheridge
“You can sleep while I drive” (not recommended when he drives alone a lot)
I’m Bad, I’m Nationwide - ZZ Top
Roll on Down the Highway - Bachman Turner Overdrive
Holiday Road - Lindsey Buckingham
Makin’ Thunderbirds - Bob Seger
Darlington County - Bruce Springsteen
Mercury Blues - Alan Jackson
Drivng My Life Away - Eddie Rabbit
…and if you and your friend share a dark sense of humor:
Last Kiss - J. Frank Wilson
Crawling From the Wreckage - Dave Edmunds
Drive Like Lightning (Crash Like Thunder) - Brian Setzer Orchestra
Transfusion - Nervous Norvus