Let’s see, Agent 47 (Hitman) vs Sam Fisher (Splinter Cell). I have no idea. They might just both die of old age after spending decades circling each other.
Between Morgan Yu of Prey and the Captain in Far Cry New Dawn… I am going to go with the Captain. That said, I am I only a few hours into either at this point. Fired up Prey from the Steam archives and then received New Dawn as a birthday gift last weekend. Morgan may get tougher but he’s not tough enough yet 
That’s kind of the thing though. My man Rô literally cannot die. And he only needs to [del]get lucky[/del]git gud once. So what if it takes him a hundred tries ? He will keep. On. Coming. Those backstabs look like they smart quite a bit, too :D.
Of course, in another universe my man Rô is real busy getting clowned over and over by a fricking ghost monk who only has a big blade-on-a-stick to his name, so there is that.
Won’t do him much good if he’s turned into a gloo snowman. Or a stack of medkits. Or a puppet. A modded-up Morgan has a lot of options.
Adam Jensen (Deus Ex) vs. the survivor in The Long Dark. Now, you’d think Jensen would win in a walk with all those fancy augs, but the survivor is actually none other than Commander Shepard who obviously survived the debacle on the Citadel and the Quiet Apocalypse is what remains on Earth following the destruction ending of Mass Effect 3. I think Adam ends up lying frozen in the snow with a wolf eating his face off.
Isn’t that what would happen no matter who else was there? I mean, it’s The Long Dark. 
Ryley Robinson from Subnautica vs. Rico Rodriguez from Just Cause 3. Under normal circumstances that would certainly be Rico, but the last time I quit Subnautica Ryley was in a fully equipped Cyclops with Mk 3 depth module & a Shield, whereas Rico had just jumped out of a burning airplane and landed somewhere in the ocean. So Ryley could probably dive out of Rico’s range before Rico could steal a boat and drop grenades on him.
Missed the edit window:
Alternatively, Ryley has a Prawn on board with a torpedo arm and some gas torpedoes in storage. So he should be able to blow Rico out of the water before Rico finds a boat.
El Presidente from Tropico or Adam Jensen from the Deus Ex series? Gonna go with the cyborg.
The Sole Survivor (Fallout 4) vs The Marvelous Miss Take.
A stealth based thief vs a well-armed wasteland killing machine.
Yeah, the Survivor wins…if she can find her.
Gorion’s Ward, a level 25 Archer with all sorts of unbalancing mod goodies, vs. a sniping/diplomacy build Courier. Like everyone else, I suppose. Also with unbalancing stuff from the East Coast side of the Fallout Universe. (I highly recommend A Tale of Two Wastelands for those who love the Fallout series. Playing Fallout 3 with New Vegas rules is worth it all by itself.)
It’s going to depend on who sees who first. Project Nevada turns everyone into glass cannons. Though I still had to sit through his insufferable speech before I could kill Ulysses with Annabelle.
The recon helmet from some Nexus mod, the one that shows life forms as glowing objects, will probably help, and Esther will no doubt finish the Ward off. Despite his ridiculous magic resistance and fire resistance. (Cloak of Balduran, Ring of Gaxx, etc…plus goodies from Lara de Vortel’s mods. Apologies for butchering her last name.) A magic longbow can’t really compete.
Both would probably crush whoever name it was who was the protagonist in Stalker: Clear Sky.
Prince Noctis Lucis Caelum (Final Fantasy XV) vs. the Doomslayer (Doom 2016).
One is the true King of Light, who can call upon the power of the gods and the mystic arms of 113 generations of Lucian kings to defeat the daemons that infest the Earth.
The other is the last Night Sentinel of Argent D’Ur, who wields a bunch of giant guns to defeat the demons that infest our plane of existence.
It just might be a tie.
No contest here. Spider-Man would kick the shit out of a version of me playing shortstop for the Oakland A’s.
Or if we take the last two before those it would be a guy named Jack Batty, who regularly makes truck deliveries all through Europe versus Jebidiah Kerbal. That might be fun to watch.