Wilma Deering
Dale Arden
Juliet Jones
Eve Jones
The Spirit started as a newspaper comic insert rather than a comic book. Will Eisner’s women were brain melting. Silken Floss. P’Gell. Lorelei Rox. Silk Satin. Sand Saref. Nylon Rose. Even good girl Ellen Dolan.
RealityChuck: Good call on Miss Lace; ditto with Blondie, running coach – old-school style has to be represented.
Rose does have a huge personality score among the newspaper-strip characters.
In the superhero comics I have to say there’s something about a 7 foot tall green lawyer who *knows *she’s in a comic book.
Nice choice.
But if you’re going there: Miele/Honey (The Scent of the Invisible/Butterscotch).
CAN WE VOTE FOR MIELE?
Okay, then, I vote for Miele!
If you’re going there, why not John Willie’s Gwendoline?
Moonbeam McSwine? Sorry, but Daisy Mae is the best in Li’l Abner as far as I’m concerned.
In Scooby-Doo I’d have to favor Daphne over Velma, all things considered. But who knows–Velma may appeal to Shaggy all the same. 
I’ve seen The Heart of Juliet Jones; the depictions of Eve–sometimes serious and introspective–appeal to me more than those of Juliet.
In the Archie comics, I sometimes see Jughead with a girl who is at least as pretty as Betty or Veronica. And sometimes she appeals to him, which is a delight. As for Midge, it’s good to see her put Moose in his place, as she often does. 
ALL of the women drawn by Mike Manley in “Judge Parker.” God forgive me, even the teenagers!
Duo Damsel from the Legion of Super Heroes. Not all that hot compared to some cited, but the ability to become two identical girls gets her a lot of points.
Druuna. If we’re going there, the answer is Druuna.
Although my answer to the OP is Psi Judge Anderson.
Miss Buxley, in Beetle Bailey
Any of the young women in Frank Cho’s comics.
Yes, Brandy Carter from Cho’s Liberty Meadows strip.
From that perspective, Triplicate Girl was hotter.
Amazing that this thread exists, considering so many users on this site are Social Justice Warrior Progressives, who believe in the Star Trek Next Generation Utopia of not judging women based on looks, yet attack President Trump for the same.
But I guess since the males on here are ranking cartoon women (how pathetic does that sound) it passes their rules.
I don’t attack Trump for judging women by their looks.
I attack him for grabbing them by the pussy.
So not just comics, but TV/movies too?
Ok, then for me:
Lana Kane
Cheryl Tunt
Skinny Pam
All these lovely ladies are from Archer.
Eldersign wrote: “Social Justice Warrior Progressives” As if that phrase has actual meaning.
Erin Esurance, who was so hot they had to take her off the air.
Bugs bunny when he put on a dress and played a girl bunny.
Yeah, but only to other bunnies. 