And let’s skip the obvious Jessica Rabbit.
I think it has to be Betty Boop, but Lois Griffin is right up there.
Pink haired esurance girl, i’m so in love with her.
Bugs Bunny. Both in and out of drag.
Red Hot Riding Hood (go to about 2:40). A cross between Jessica Rabbit and Betty Boop.
ITT sad nerds revealed.
Personally, anyone voiced by Grey Delisle.
Moka Akashiya or Mikuru Asahina or Lala Satalin Deviluke – just 3 that come to mind. 
Mom Turner.
You’d choose Mikuru over Yuki!?
Yuki with or Yuki without glasses? Actually, I’d prefer Yuki for a long term relationship – but sexiness isn’t really her strong feature.
Firestar is up there. She makes me feel tingly all over, like climbing the rope in gym class. She’s smart, confident, a little sassy, and she looks hot in her costume.
I’m tempted to throw in the Baroness, but her portrayal in the cartoons that makes her sound like a Transylvanian cross dresser is like a bucket of cold water in your face.
Gadget from the Rescue Rangers.
Blondie Boopadoop Bumstead. And she can cook.
Velma Dinkley. But that’s just me.
With, of course (Kyon’s an idiot!).
I beg to differ (link goes to a photobucket image of a scan of an official promotional pic from an anime magazine)
Samurai Jack!
If I’m in the mood for dumb and blonde, there’s the Pussycat Melody.
Seconding Lois Griffin. She’s all three of Dan Savage’s three Gs, plus she’s smokin’, even after three kids.
Blondie Bumstead. Grrrrrowl.
ETA: Damn you, Sigmagirl! But yeah.
She looks pretty good in that – without her glasses, and not in her normal school uniform (which, of course, she started wearing three years before going to North High School, and hardly ever stops wearing).